The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis

Prion ailments are a novel group of infectious power neurodegenerative issues to which there are not any cures. Though prion infections don’t stimulate adaptive immune responses in contaminated people, the actions of sure immune cell populations can have a big impression on illness pathogenesis. After an infection, the concentrating on of peripherally-acquired prions to particular immune cells within the secondary lymphoid organs (SLO), such because the lymph nodes and spleen, is important for the environment friendly transmission of illness to the mind.

As soon as the prions attain the mind, interactions with different immune cell populations can present both host safety or speed up the neurodegeneration. On this evaluate, we offer an in depth account of how elements corresponding to irritation, ageing and pathogen co-infection can have an effect on prion illness pathogenesis and susceptibility. For instance, we talk about how modifications to the abundance, operate and activation standing of particular immune cell populations can have an effect on the transmission of prion ailments by peripheral routes. We additionally describe how the results of systemic irritation on sure glial cell subsets within the brains of contaminated people can speed up the neurodegeneration.

An in depth understanding of the elements that have an effect on prion illness transmission and pathogenesis is important for the event of novel intervention methods. Human prion illness surveillance is important to detect potential circumstances of variant Creutzfeldt-Jakob illness and different acquired types of prion illness in america. Outcomes are introduced right here that describe 12 years of surveillance in Washington, the one US state that has reported the presence of traditional bovine spongiform encephalopathy, an animal prion illness that has been proven to transmit to people.

Perception From Animals Immune to Prion Illnesses: Deciphering the Genotype – Morphotype – Phenotype Code for the Prion Protein

Prion ailments are a gaggle of neurodegenerative ailments endemic in people and a number of other ruminants brought on by the misfolding of native prion protein (PrP) into pathological conformations. Experimental work and the mad-cow epidemic of the 1980s uncovered a large spectrum of animal susceptibility to prion ailments, together with a couple of extremely resistant animals: horses, rabbits, pigs, and canine/canids. The variable susceptibility to illness affords a novel alternative to uncover the mechanisms governing PrP misfolding, neurotoxicity, and transmission.

Earlier work signifies that PrP-intrinsic variations (sequence) are the primary contributors to illness susceptibility. A number of residues have been cited as important for encoding PrP conformational stability in prion-resistant animals, together with D/E159 in canine, S167 in horse, and S174 in rabbit and pig PrP (all based on human numbering). These amino acids alter PrP properties in quite a lot of assays, however we nonetheless don’t clearly perceive the structural correlates of PrP toxicity. Further perception could be extracted from comparative structural research, adopted by molecular dynamics simulations of chosen mutations, and testing in manipulable animal fashions.

Our working speculation is that protecting amino acids generate extra compact and secure constructions in a C-terminal subdomain of the PrP globular area. We’ll discover this concept on this evaluate and establish subdomains throughout the globular area that will maintain the important thing to unravel how conformational stability and illness susceptibility are encoded in PrP.

An Replace on Autophagy in Prion Illnesses

Autophagy is a dynamic intracellular mechanism concerned in protein and organelle turnover by way of lysosomal degradation. When correctly regulated, autophagy helps regular mobile and developmental processes, whereas defects in autophagic degradation have been related to a number of pathologies, together with prion ailments. Prion ailments, or transmissible spongiform encephalopathies (TSE), are a gaggle of deadly neurodegenerative issues characterised by the buildup of the pathological misfolded isoform (PrPSc) of the physiological mobile prion protein (PrPc) within the central nervous system.

Autophagic vacuoles have been described in experimental fashions of TSE and within the pure illness in people. The exact connection of this course of with prion-related neuropathology, and even whether or not autophagy is totally useful or pathogenic throughout neurodegeneration, is poorly understood. Thus, the organic function of autophagy in these ailments remains to be open to debate. Over the past years, researchers have used a variety of morphological, genetic and biochemical strategies to watch and manipulate the autophagic pathway and thus decide the particular function of this course of in TSE. It has been urged that PrPc might play a vital function in modulating the autophagic pathway in neuronal cells, and the presence of irregular autophagic exercise has been ceaselessly noticed in a number of fashions of TSE each in vitro and in vivo, in addition to in human prion ailments.

Altogether, these findings recommend that autophagy is implicated in prion neuropathology and factors to an impairment or failure of the method, doubtlessly contributing to the pathogenesis of the illness. Moreover, autophagy is now rising as a number protection response in controlling prion an infection that performs a protecting function by facilitating the clearance of aggregation-prone proteins collected inside neurons.

Bovine Major prion protein(PRNP) ELISA kit
1-CSB-EL018739BO	Cusabio	EUR 1080.00 EUR 6571.20 EUR 3480.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Bovine Major prion protein(PRNP) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Major prion protein(PRNP) ELISA kit
CSB-EL018739HU-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Major prion protein (PRNP) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Major prion protein(PRNP) ELISA kit
1-CSB-EL018739HU	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Major prion protein(PRNP) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Goat Major prion protein(PRNP) ELISA kit
E06M0432-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Major prion protein(PRNP) ELISA kit
E06M0432-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Major prion protein(PRNP) ELISA kit
E06M0432-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Major prion protein(PRNP) ELISA kit
E04M0432-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Major prion protein(PRNP) ELISA kit
E04M0432-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Major prion protein(PRNP) ELISA kit
E04M0432-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Major prion protein(PRNP) ELISA kit
E03M0432-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Major prion protein(PRNP) ELISA kit
E03M0432-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Major prion protein(PRNP) ELISA kit
E03M0432-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human PRNP(Major prion protein) ELISA Kit
EH2469	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Mouse Prnp( Major prion protein) ELISA Kit
EM0811	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Mouse Prnp/ Major prion protein ELISA Kit
E1203Mo	Sunlong	1 Kit	EUR 758.4

Human PRNP/ Major prion protein ELISA Kit
E2046Hu	Sunlong	1 Kit	EUR 726

Rat Major prion protein(PRNP) ELISA kit
E02M0432-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Major prion protein(PRNP) ELISA kit
E02M0432-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Major prion protein(PRNP) ELISA kit
E02M0432-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Major prion protein(PRNP) ELISA kit
E07M0432-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Major prion protein(PRNP) ELISA kit
E07M0432-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Major prion protein(PRNP) ELISA kit
E07M0432-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Major prion protein(PRNP) ELISA kit
E08M0432-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Major prion protein(PRNP) ELISA kit
E08M0432-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Major prion protein(PRNP) ELISA kit
E08M0432-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Mouse Major prion protein
EK4954	SAB	96 tests	EUR 723.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Major prion protein in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Major prion protein
EK4955	SAB	96 tests	EUR 723.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Major prion protein in samples from serum, plasma, tissue homogenates and other biological fluids.

Bovine Major prion protein, PRNP ELISA KIT
ELI-45406b	Lifescience Market	96 Tests	EUR 1113.6

Porcine Major prion protein, PRNP ELISA KIT
ELI-19754p	Lifescience Market	96 Tests	EUR 1113.6

Canine Major prion protein, PRNP ELISA KIT
ELI-36236d	Lifescience Market	96 Tests	EUR 1113.6

Rabbit Major prion protein, PRNP ELISA KIT
ELI-36961Ra	Lifescience Market	96 Tests	EUR 1113.6

Human Major prion protein(PRNP) ELISA kit
E01M0432-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Major prion protein(PRNP) ELISA kit
E01M0432-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Major prion protein(PRNP) ELISA kit
E01M0432-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Prnp/ Major prion protein ELISA Kit
E0804Ra	Sunlong	1 Kit	EUR 775.2

Rat Major prion protein, Prnp ELISA KIT
ELI-12731r	Lifescience Market	96 Tests	EUR 1063.2

Human Major prion protein, PRNP ELISA KIT
ELI-15623h	Lifescience Market	96 Tests	EUR 988.8

Mouse Major prion protein, Prnp ELISA KIT
ELI-16780m	Lifescience Market	96 Tests	EUR 1038

Major Prion Protein (PRNP) Protein
20-abx263341	Abbexa	EUR 1930.80 EUR 393.60 EUR 276.00	100 ug 10 ug 2 µg

Prnp ELISA Kit| Mouse Major prion protein ELISA Kit
EF012787	Lifescience Market	96 Tests	EUR 826.8

Major Prion Protein (CD230) Antibody
abx139819-01mg	Abbexa	0.1 mg	EUR 610.8

Major Prion Protein (CD230) Antibody
20-abx141693	Abbexa	EUR 444.00 EUR 727.20 EUR 360.00	100 ul 200 ul 50 ul

Major Prion Protein (PRNP) Antibody
20-abx002019	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Major Prion Protein (PRNP) Antibody
20-abx319681	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Major Prion Protein (PRNP) Antibody
20-abx333875	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Major Prion Protein (CD230) Antibody
abx415314-01mg	Abbexa	0.1 mg	EUR 543.6

Major Prion Protein (CD230) Antibody
abx415315-01mg	Abbexa	0.1 mg	EUR 543.6

Major Prion Protein (CD230) Antibody
abx415316-01mg	Abbexa	0.1 mg	EUR 543.6

Major Prion Protein (CD230) Antibody
abx412470-01ml	Abbexa	0.1 ml	EUR 844.8

Rat Major prion protein (Prnp)
1-CSB-EP018739RA	Cusabio	EUR 606.00 EUR 318.00 EUR 2192.40 EUR 919.20 EUR 1461.60 EUR 402.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rat Major prion protein(Prnp) expressed in E.coli

Rat Major prion protein (Prnp)
1-CSB-YP018739RA	Cusabio	EUR 604.80 EUR 318.00 EUR 2198.40 EUR 915.60 EUR 1459.20 EUR 400.80	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rat Major prion protein(Prnp) expressed in Yeast

Chicken PRNP/ Major prion protein homolog ELISA Kit
E0067Ch	Sunlong	1 Kit	EUR 860.4

Guinea pig Major prion protein(PRNP) ELISA kit
E05M0432-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Major prion protein(PRNP) ELISA kit
E05M0432-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Major prion protein(PRNP) ELISA kit
E05M0432-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Major prion protein(PRNP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Chicken Major prion protein homolog, PRNP ELISA KIT
ELI-21772c	Lifescience Market	96 Tests	EUR 1113.6

ELISA kit for Rabbit Major prion protein (PRNP)
KTE90055-48T	Abbkine	48T	EUR 424.8
Description: Quantitative sandwich ELISA for measuring Rabbit Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rabbit Major prion protein (PRNP)
KTE90055-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Rabbit Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rabbit Major prion protein (PRNP)
KTE90055-96T	Abbkine	96T	EUR 686.4
Description: Quantitative sandwich ELISA for measuring Rabbit Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Sheep Major prion protein (PRNP)
KTE110020-48T	Abbkine	48T	EUR 424.8
Description: Quantitative sandwich ELISA for measuring Sheep Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Sheep Major prion protein (PRNP)
KTE110020-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Sheep Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Sheep Major prion protein (PRNP)
KTE110020-96T	Abbkine	96T	EUR 686.4
Description: Quantitative sandwich ELISA for measuring Sheep Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Major prion protein (PRNP)
KTE100420-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Rat Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Major prion protein (PRNP)
KTE100420-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Rat Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Major prion protein (PRNP)
KTE100420-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Rat Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Major prion protein (PRNP)
KTE61138-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Major prion protein (PRNP)
KTE61138-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Human Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Major prion protein (PRNP)
KTE61138-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Bovine Major prion protein (PRNP)
KTE10174-48T	Abbkine	48T	EUR 424.8
Description: Quantitative sandwich ELISA for measuring Bovine Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Bovine Major prion protein (PRNP)
KTE10174-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Bovine Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Bovine Major prion protein (PRNP)
KTE10174-96T	Abbkine	96T	EUR 686.4
Description: Quantitative sandwich ELISA for measuring Bovine Major prion protein (PRNP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Major Prion Protein (PRNP) Antibody (HRP)
20-abx319682	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Major Prion Protein (PRNP) Antibody (FITC)
20-abx319683	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Major Prion Protein (PRNP) Antibody (Biotin)
20-abx319684	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Major Prion Protein (PRNP) Antibody (HRP)
20-abx336435	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Major Prion Protein (PRNP) Antibody (FITC)
20-abx336436	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Major Prion Protein (PRNP) Antibody (Biotin)
20-abx336437	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Mouse Major prion protein (PrnP) ELISA Kit, 96 tests, Quantitative
9220	Alpha Diagnostics	1 Kit	EUR 927.6

Monkey Major vault protein ELISA kit
E09M0355-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Major vault protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major vault protein ELISA kit
E09M0355-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Major vault protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major vault protein ELISA kit
E09M0355-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Major vault protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Shadow of prion protein(SPRN) ELISA kit
E09S0399-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Shadow of prion protein(SPRN) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Shadow of prion protein(SPRN) ELISA kit
E09S0399-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Shadow of prion protein(SPRN) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Shadow of prion protein(SPRN) ELISA kit
E09S0399-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Shadow of prion protein(SPRN) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major Vault Protein (MVP) ELISA Kit
abx359557-96tests	Abbexa	96 tests	EUR 990

Monkey Major outer membrane protein ELISA kit
E09M0280-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Major outer membrane protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major outer membrane protein ELISA kit
E09M0280-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Major outer membrane protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major outer membrane protein ELISA kit
E09M0280-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Major outer membrane protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major urinary protein 1 ELISA kit
E09M0281-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major urinary protein 1 ELISA kit
E09M0281-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major urinary protein 1 ELISA kit
E09M0281-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey major acute phase protein (MAP) ELISA kit
E09M0379-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey major acute phase protein (MAP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey major acute phase protein (MAP) ELISA kit
E09M0379-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey major acute phase protein (MAP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey major acute phase protein (MAP) ELISA kit
E09M0379-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey major acute phase protein (MAP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major histocompatibility complex I ELISA kit
E09M0276-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Major histocompatibility complex I in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major histocompatibility complex I ELISA kit
E09M0276-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Major histocompatibility complex I in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major histocompatibility complex I ELISA kit
E09M0276-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Major histocompatibility complex I in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major histocompatibility complex III ELISA kit
E09M0279-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Major histocompatibility complex III in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major histocompatibility complex III ELISA kit
E09M0279-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Major histocompatibility complex III in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Major histocompatibility complex III ELISA kit
E09M0279-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Major histocompatibility complex III in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Prion Protein (PRNP) ELISA Kit
20-abx156738	Abbexa	EUR 8534.40 EUR 4550.40 EUR 1054.80	10 × 96 tests 5 × 96 tests 96 tests

Mouse Prion Protein (PRNP) ELISA Kit
20-abx156832	Abbexa	EUR 8684.40 EUR 4626.00 EUR 1074.00	10 × 96 tests 5 × 96 tests 96 tests

Human Prion Protein (PRNP) ELISA Kit
abx251835-96tests	Abbexa	96 tests	EUR 895.2

Mouse Prion Protein (PRNP) ELISA Kit
abx255159-96tests	Abbexa	96 tests	EUR 895.2

Cow Prion Protein (PRNP) ELISA Kit
abx521103-96tests	Abbexa	96 tests	EUR 1093.2

Chicken Prion Protein (PRNP) ELISA Kit
abx521104-96tests	Abbexa	96 tests	EUR 1093.2

Dog Prion Protein (PRNP) ELISA Kit
abx521105-96tests	Abbexa	96 tests	EUR 1093.2

Pig Prion Protein (PRNP) ELISA Kit
abx521108-96tests	Abbexa	96 tests	EUR 1093.2

Rat Prion Protein (PRNP) ELISA Kit
abx521109-96tests	Abbexa	96 tests	EUR 801.6

Mouse Prion Protein (PRNP) ELISA Kit
abx571234-96tests	Abbexa	96 tests	EUR 801.6

Human Prion Protein (PRNP) ELISA Kit
abx573091-96tests	Abbexa	96 tests	EUR 801.6

Rat Prion Protein (PRNP) ELISA Kit
20-abx258974	Abbexa	EUR 8684.40 EUR 4626.00 EUR 1074.00	10 × 96 tests 5 × 96 tests 96 tests

Human Prion Protein (PRNP) ELISA Kit
DLR-PRNP-Hu-48T	DL Develop	48T	EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Prion Protein (PRNP) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Prion Protein (PRNP) ELISA Kit
DLR-PRNP-Hu-96T	DL Develop	96T	EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Prion Protein (PRNP) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Prion Protein (PRNP) ELISA Kit
DLR-PRNP-Mu-48T	DL Develop	48T	EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Prion Protein (PRNP) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Prion Protein (PRNP) ELISA Kit
DLR-PRNP-Mu-96T	DL Develop	96T	EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Prion Protein (PRNP) in samples from tissue homogenates, cell lysates or other biological fluids.

Bovine Prion Protein(PP) ELISA Kit
GA-E0040BV-48T	GenAsia Biotech	48T	EUR 403.2

Bovine Prion Protein(PP) ELISA Kit
GA-E0040BV-96T	GenAsia Biotech	96T	EUR 640.8

Human Prion Protein (PRNP) ELISA Kit
RD-PRNP-Hu-48Tests	Reddot Biotech	48 Tests	EUR 600

Human Prion Protein (PRNP) ELISA Kit
RD-PRNP-Hu-96Tests	Reddot Biotech	96 Tests	EUR 830.4

Mouse Prion Protein (PRNP) ELISA Kit
RD-PRNP-Mu-48Tests	Reddot Biotech	48 Tests	EUR 613.2

Mouse Prion Protein (PRNP) ELISA Kit
RD-PRNP-Mu-96Tests	Reddot Biotech	96 Tests	EUR 850.8

Human Prion Protein (PRNP) ELISA Kit
RDR-PRNP-Hu-48Tests	Reddot Biotech	48 Tests	EUR 626.4

Human Prion Protein (PRNP) ELISA Kit
RDR-PRNP-Hu-96Tests	Reddot Biotech	96 Tests	EUR 868.8

Mouse Prion Protein (PRNP) ELISA Kit
RDR-PRNP-Mu-48Tests	Reddot Biotech	48 Tests	EUR 640.8

Mouse Prion Protein (PRNP) ELISA Kit
RDR-PRNP-Mu-96Tests	Reddot Biotech	96 Tests	EUR 890.4

Human Prion Protein (PRNP) ELISA Kit
SEB680Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Prion Protein (PRNP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Prion Protein (PRNP) ELISA Kit
SEB680Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Prion Protein (PRNP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Prion Protein (PRNP) ELISA Kit
SEB680Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Prion Protein (PRNP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Prion Protein (PRNP) ELISA Kit
SEB680Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Prion Protein (PRNP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Prion Protein (PRNP) ELISA Kit
4-SEB680Hu	Cloud-Clone	EUR 5463.60 EUR 2886.00 EUR 735.60	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Prion Protein (PRNP) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Prion Protein (PRNP) ELISA Kit
SEB680Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5552.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Prion Protein (PRNP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Prion Protein (PRNP) ELISA Kit
SEB680Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 562.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Prion Protein (PRNP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Prion Protein (PRNP) ELISA Kit
SEB680Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 752.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Prion Protein (PRNP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Prion Protein (PRNP) ELISA Kit
SEB680Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3024.07
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Prion Protein (PRNP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Prion Protein (PRNP) ELISA Kit
4-SEB680Mu	Cloud-Clone	EUR 5612.40 EUR 2965.20 EUR 752.40	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Prion Protein (PRNP) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Prion Protein (PRNP) ELISA Kit
SEB680Ra-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 6149.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Prion Protein (PRNP) in tissue homogenates, cell lysates and other biological fluids.

Rat Prion Protein (PRNP) ELISA Kit
SEB680Ra-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 611.57
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Prion Protein (PRNP) in tissue homogenates, cell lysates and other biological fluids.

Rat Prion Protein (PRNP) ELISA Kit
SEB680Ra-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 822.24
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Prion Protein (PRNP) in tissue homogenates, cell lysates and other biological fluids.

Rat Prion Protein (PRNP) ELISA Kit
SEB680Ra-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3340.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Prion Protein (PRNP) in tissue homogenates, cell lysates and other biological fluids.

Rat Prion Protein (PRNP) ELISA Kit
4-SEB680Ra	Cloud-Clone	EUR 6210.00 EUR 3280.80 EUR 823.20	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Prion Protein (PRNP) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Prion Protein(PRNP)ELISA Kit
QY-E01716	Qayee Biotechnology	96T	EUR 433.2

Human Prion Protein ELISA Kit (PRNP)
RK02138	Abclonal	96 Tests	EUR 625.2

Mouse Prion Protein ELISA Kit (PRNP)
RK03137	Abclonal	96 Tests	EUR 625.2

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed
ELISA-1	Alpha Diagnostics	1	EUR 242.4

Since autophagy is likely one of the pathways of PrPSc degradation, and drug-induced stimulation of autophagic flux (the dynamic technique of autophagic degradation exercise) produces anti-prion results, new remedies primarily based on its activation have been examined to develop therapeutic methods for prion ailments. On this evaluate, we summarize earlier and up to date findings regarding the function of autophagy in TSE.