A prognosis-predictive nomogram of ovarian cancer with two immune

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Evaluation of key genes and pathways in breast ductal carcinoma in situ

Breast most cancers (BC) stays the most common most cancers in females. Attributable to this truth, the present analysis aimed to determine key genes involved inside the carcinogenesis of BC and to find their prognostic values by integrating bioinformatics devices. The gene expression profiles of 46 ductal carcinoma in situ (DCIS) and three common breast tissues from the GSE59248 dataset have been downloaded. Differentially expressed genes (DEGs) have been subsequently acknowledged using the web machine GEO2R and a helpful enrichment analysis was carried out. In addition to, a protein-protein interaction (PPI) neighborhood was constructed and the best eight hub genes have been acknowledged.

 

The prognostic values of the hub genes have been further investigated. An entire of 316 DEGs, along with 32 upregulated and 284 downregulated genes, have been acknowledged. Furthermore, eight hub genes, along with lipase E hormone delicate type, patatin like phospholipase space containing 2, adiponectin C1Q and collagen space containing (ADIPOQ), peroxisome proliferator activated receptor γ (PPARG), fatty acid binding protein 4 (FABP4), diacylglycerol O-acyltransferase 2, lipoprotein lipase (LPL) and leptin (LEP), have been acknowledged from the PPI neighborhood.

 

The downregulated expression of ADIPOQ, PPARG, FABP4, LPL and LEP was significantly associated to poor whole survival in victims with DCIS. Attributable to this truth, these genes may operate potential biomarkers for prognosis prediction. Nonetheless, further investigation is required to validate the outcomes obtained inside the present analysis.

 

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A prognosis-predictive nomogram of ovarian most cancers with two immune-related genes: CDC20B and PNPLA5

 

Ovarian carcinoma (OV) is probably going one of the lethal gynecological malignancies globally, and the final 5-year survival cost of OV was 47% in 2018 based mostly on American info. To increase the survival cost of victims with OV, many researchers have sought to determine biomarkers that act as every prognosis-predictive markers and treatment targets.

 

Nonetheless, most of these have not been acceptable for scientific software program. The present analysis geared towards establishing a predictive prognostic nomogram of OV using the genes acknowledged by combining The Most cancers Genome Atlas (TCGA) dataset for OV with the immune score calculated by the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression info algorithm. Firstly, the algorithm was used to calculate the immune score of victims with OV inside the TCGA-OV dataset.

 

Secondly, differentially expressed genes (DEGs) between excessive and low immune score tissues have been acknowledged, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis was carried out to predict the options of these DEGs. Thirdly, univariate, multivariate and Lasso Cox’s regression analyses have been carried out step-by-step, and 6 prognosis-relatedDEGs have been acknowledged.

 

Then, Kaplan-Myer survival curves have been generated for these genes and validated by evaluating their expression ranges to further slender the fluctuate of DEGs and to calculate the hazard score. Two genes have been acknowledged, cell division cycle 20B and patatin-like phospholipase space containing 5, which have been every confirmed to have elevated expression ranges in OV tissues and to be significantly associated to the prognosis of OV.

 

Subsequent, a nomogram was created using these two genes and age, and using the receiver working attribute (ROC) curve and calibration curve, the effectiveness of the nomogram was validated. Lastly, an exterior validation was carried out for this nomogram. The ROC confirmed that the areas beneath the curve (AUCs) of the 3- and 5-year whole survival predictions for the nomogram have been 0.678 and 0.62, respectively. Moreover, the ROC of the outside validation model confirmed that the AUCs of the 3- and 5-year have been 0.699 and 0.643, respectively, demonstrating the effectiveness of the generated nomogram. In conclusion, the present analysis has acknowledged two immune-related genes as biomarkers that reliably predict whole survival in OV. These biomarkers can also be potential molecular targets of immune treatment to cope with victims with OV.

 

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EUR 2704.8

Rapamycin, 10mg

R5312-10mg each
EUR 244.8

Rapamycin-d3

T12691-10mg 10mg Ask for price
Description: Rapamycin-d3

Rapamycin-d3

T12691-1g 1g Ask for price
Description: Rapamycin-d3

Rapamycin-d3

T12691-1mg 1mg Ask for price
Description: Rapamycin-d3

Rapamycin-d3

T12691-50mg 50mg Ask for price
Description: Rapamycin-d3

Rapamycin-d3

T12691-5mg 5mg Ask for price
Description: Rapamycin-d3

Seco Rapamycin

T38963-10mg 10mg Ask for price
Description: Seco Rapamycin

Seco Rapamycin

T38963-1g 1g Ask for price
Description: Seco Rapamycin

Seco Rapamycin

T38963-1mg 1mg Ask for price
Description: Seco Rapamycin

Seco Rapamycin

T38963-50mg 50mg Ask for price
Description: Seco Rapamycin

Seco Rapamycin

T38963-5mg 5mg Ask for price
Description: Seco Rapamycin

Optically clear sealing film for qPCR, Strong Bond, for PP plates, 100/pk

MS1000-PCR2 1 each
EUR 149.35

Sirolimus (Rapamycin)

100766 25.0mg
EUR 90

Rapamycin (Sirolimus)

E1KS1039 50mg
EUR 120

Rapamycin (Sirolimus)

A8167-100 100 mg
EUR 154
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

A8167-25 25 mg
EUR 74
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

A8167-5 5 mg
EUR 33
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

A8167-5.1 10 mM (in 1mL DMSO)
EUR 48
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

A8167-S Evaluation Sample
EUR 22
Description: Original antifungal antibiotic

EZSolution? Rapamycin

1746-5 each
EUR 326.4

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 24-45 µm

DAG-YS23-27 25 mL
EUR 850

rapamycin derivative 1

R454500 25mg
EUR 1800

rapamycin derivative 2

R574880 100mg
EUR 9200

Rapamycin [CAS# 53123-88-9]

R-5000 50 mg
EUR 48

OOMC00007-10MG - Rapamycin

OOMC00007-10MG 10mg
EUR 69

OOMC00007-50MG - Rapamycin

OOMC00007-50MG 50mg
EUR 249

Rapamycin-31,42-Diester Impurity

R124015 50mg
EUR 1938

33-O-Formyl Rapamycin

F699010 10mg
EUR 1728

Seco Rapamycin (sodium salt)

HY-19555A 1mg
EUR 207.6

7-O-Demethyl rapamycin

T25882-10mg 10mg Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin

T25882-1g 1g Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin

T25882-1mg 1mg Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin

T25882-50mg 50mg Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin

T25882-5mg 5mg Ask for price
Description: 7-O-Demethyl rapamycin

Seco Rapamycin sodium salt

T19558-10mg 10mg Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt

T19558-1g 1g Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt

T19558-1mg 1mg Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt

T19558-50mg 50mg Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt

T19558-5mg 5mg Ask for price
Description: Seco Rapamycin sodium salt

42-(2-Tetrazolyl)rapamycin

HY-12424A 1mg
EUR 241.2

42-(2-Tetrazolyl)rapamycin

T10158-10mg 10mg Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

T10158-1g 1g Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

T10158-1mg 1mg Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

T10158-50mg 50mg Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

T10158-5mg 5mg Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

28-O-Formyl Rapamycin (>80%)

H849200 100mg
EUR 695

Foil seals, strong bonding for cold storage (-200 to 110°C) and DMSO, for PP plates, 100/pk

MS1000-F2 1 each
EUR 149.35

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, Low Capacity

DAG-YS23-28 25 mL
EUR 850

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, High Capacity

DAG-YS23-29 25 mL
EUR 850

7-O-Demethyl Rapamycin (~80%)

D231240 10mg
EUR 1903
Description: 151519-50-5

Rapamycin Dialdehyde (Technical Grade)

R124250 10mg
EUR 770
Description: 500733-49-3

28-Ethyl-d4-hydroxy Rapamycin

E678642 25mg
EUR 4500

Estrogen receptor (ER) IHC control with strong, moderate, low/negative expressersHumanBreastBreastIHC control

ERC083 1.5mm
EUR 50

Rapamycin-13C,d3 (contains d0) Technical Grade

R124003 10mg
EUR 1984

Rapamycin-d3 (contains d0) Technical Grade

R124002 10mg
EUR 230
Description: 392711-19-2

Rat Mammalian target of rapamycin ELISA kit

E02M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Mammalian target of rapamycin ELISA kit

E02M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Mammalian target of rapamycin ELISA kit

E02M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Mammalian target of rapamycin ELISA kit

E07M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Mammalian target of rapamycin ELISA kit

E07M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Mammalian target of rapamycin ELISA kit

E07M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Mammalian target of rapamycin ELISA kit

E08M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Mammalian target of rapamycin ELISA kit

E08M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Mammalian target of rapamycin ELISA kit

E08M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Mammalian target of rapamycin ELISA kit

E01A14486 96T
EUR 700
Description: ELISA

Goat Mammalian target of rapamycin ELISA kit

E01A49394 96T
EUR 700
Description: ELISA

Goat Mammalian target of rapamycin ELISA kit

E06M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Mammalian target of rapamycin ELISA kit

E06M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Mammalian target of rapamycin ELISA kit

E06M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

(19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)

R124010 100mg
EUR 1242
Description: 148554-65-8

Human Mammalian target of rapamycin ELISA kit

E01A5739 96T
EUR 700
Description: ELISA

Mouse Mammalian target of rapamycin ELISA kit

E01A23231 96T
EUR 700
Description: ELISA

Sheep Mammalian target of rapamycin ELISA kit

E01A101687 96T
EUR 700
Description: ELISA

Human Mammalian target of rapamycin ELISA kit

E01M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Mammalian target of rapamycin ELISA kit

E01M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Mammalian target of rapamycin ELISA kit

E01M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Mammalian target of rapamycin ELISA kit

E03M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Mammalian target of rapamycin ELISA kit

E03M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Mammalian target of rapamycin ELISA kit

E03M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Mammalian target of rapamycin ELISA kit

E01A31960 96T
EUR 700
Description: ELISA

Canine Mammalian target of rapamycin ELISA kit

E01A66824 96T
EUR 700
Description: ELISA

Rabbit Mammalian target of rapamycin ELISA kit

E04M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Mammalian target of rapamycin ELISA kit

E04M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Mammalian target of rapamycin ELISA kit

E04M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Bovine Mammalian target of rapamycin ELISA kit

E01A84261 96T
EUR 700
Description: ELISA

Monkey Mammalian target of rapamycin ELISA kit

E01A75541 96T
EUR 700
Description: ELISA

Monkey Mammalian target of rapamycin ELISA kit

E09M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Mammalian target of rapamycin ELISA kit

E09M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Mammalian target of rapamycin ELISA kit

E09M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Porcine Mammalian target of rapamycin ELISA kit

E01A58112 96T
EUR 700
Description: ELISA

Chicken Mammalian target of rapamycin ELISA kit

E01A92978 96T
EUR 700
Description: ELISA

Rat mammalian target of rapamycin(mTOR)ELISA Kit

GA-E0434RT-48T 48T
EUR 380.4

Rat mammalian target of rapamycin(mTOR)ELISA Kit

GA-E0434RT-96T 96T
EUR 595.2

Rat mammalian target of rapamycin(mTOR) ELISA Kit

NSL1333r 96 Tests
EUR 498

Rat mammalian target of rapamycin(mTOR)ELISA Kit

QY-E11218 96T
EUR 433.2

Rat Mammalian Target of Rapamycin(mTOR)ELISA Kit

YLA1487RA-48T 48T Ask for price

Rat Mammalian Target of Rapamycin(mTOR)ELISA Kit

YLA1487RA-96T 96T Ask for price

42-O-tert-Butyldimethylsilyloxyethyl Rapamycin

B691475 100mg
EUR 471
Description: 159351-68-5

Human mTOR(MammalianTarget of Rapamycin) ELISA Kit

ELK9591-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human mTOR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human mTOR. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human mTOR, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human mTOR in the samples is then determined by comparing the OD of the samples to the standard curve.

Human mTOR(MammalianTarget of Rapamycin) ELISA Kit

ELK9591-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human mTOR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human mTOR. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human mTOR, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human mTOR in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Mammalian Target of Rapamycin (mTOR) CLIA Kit

abx195664-96tests 96 tests
EUR 990

Goat Mammalian target of rapamycin(mTOR) ELISA Kit

NSL0387Gt 96T
EUR 528

Human mTOR -Mammalian Target of Rapamycin- CLIA Kit

E-CL-H1050-24Tests 24 Tests
EUR 180
Description: Sandwich

Human mTOR -Mammalian Target of Rapamycin- CLIA Kit

E-CL-H1050-48Tests 48 Tests
EUR 546
Description: Sandwich

Human mTOR -Mammalian Target of Rapamycin- CLIA Kit

E-CL-H1050-96Tests 96 Tests
EUR 682
Description: Sandwich

Human mTOR -Mammalian Target of Rapamycin- CLIA Kit

E-CL-H1050-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human mTOR -Mammalian Target of Rapamycin- CLIA Kit

E-CL-H1050-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Guinea Pig Mammalian target of rapamycin ELISA kit

E01A40674 96T
EUR 700
Description: ELISA

Guinea pig Mammalian target of rapamycin ELISA kit

E05M0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Mammalian target of rapamycin ELISA kit

E05M0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Mammalian target of rapamycin ELISA kit

E05M0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Mammalian target of rapamycin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human mTOR (Mammalian Target of Rapamycin) ELISA Kit

EKE60994-5x96T 5x96T
EUR 3124.08

Human mTOR (Mammalian Target of Rapamycin) ELISA Kit

EKE60994-96T 96T
EUR 657.7

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