A prognosis-predictive nomogram of ovarian cancer with two immune

Evaluation of key genes and pathways in breast ductal carcinoma in situ

Breast most cancers (BC) stays the most common most cancers in females. Attributable to this truth, the present analysis aimed to determine key genes involved inside the carcinogenesis of BC and to find their prognostic values by integrating bioinformatics devices. The gene expression profiles of 46 ductal carcinoma in situ (DCIS) and three common breast tissues from the GSE59248 dataset have been downloaded. Differentially expressed genes (DEGs) have been subsequently acknowledged using the web machine GEO2R and a helpful enrichment analysis was carried out. In addition to, a protein-protein interaction (PPI) neighborhood was constructed and the best eight hub genes have been acknowledged.

 

The prognostic values of the hub genes have been further investigated. An entire of 316 DEGs, along with 32 upregulated and 284 downregulated genes, have been acknowledged. Furthermore, eight hub genes, along with lipase E hormone delicate type, patatin like phospholipase space containing 2, adiponectin C1Q and collagen space containing (ADIPOQ), peroxisome proliferator activated receptor γ (PPARG), fatty acid binding protein 4 (FABP4), diacylglycerol O-acyltransferase 2, lipoprotein lipase (LPL) and leptin (LEP), have been acknowledged from the PPI neighborhood.

 

The downregulated expression of ADIPOQ, PPARG, FABP4, LPL and LEP was significantly associated to poor whole survival in victims with DCIS. Attributable to this truth, these genes may operate potential biomarkers for prognosis prediction. Nonetheless, further investigation is required to validate the outcomes obtained inside the present analysis.

 

Trametinib
HY-10999	MedChemExpress	100mg	EUR 465.38
Description: Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

Trametinib
MBS3606330-100mg	MyBiosource	100mg	EUR 245

Trametinib
MBS3606330-10mg	MyBiosource	10mg	EUR 200

Trametinib
MBS3606330-200mg	MyBiosource	200mg	EUR 275

Trametinib
MBS3606330-50mg	MyBiosource	50mg	EUR 215

Trametinib
MBS3606330-5x200mg	MyBiosource	5x200mg	EUR 920

Trametinib
T2125-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Trametinib

Trametinib
T2125-1g	TargetMol Chemicals	1g	Ask for price
Description: Trametinib

Trametinib
T2125-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Trametinib

Trametinib
T2125-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Trametinib

Trametinib
T2125-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Trametinib

Trametinib-13C6
C988931	Toronto Research Chemicals	0.5mg	EUR 4669

Trametinib-13C6
HY-10999S1	MedChemExpress	1mg	Ask for price
Description: Trametinib-13C6 is the 13C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

Ripa lysate (strong)
E1WP106	EnoGene	50ML	EUR 60

Trametinib-13C,d3
HY-10999S2	MedChemExpress	1mg	EUR 1007.59
Description: Trametinib-13C,d3 is the 13C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

Trametinib-d4
HY-10999S	MedChemExpress	1mg	Ask for price
Description: Trametinib-d4 is the deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

Trametinib-d4
T712602	Toronto Research Chemicals	100mg	EUR 4500

Deiodo Trametinib
D397050	Toronto Research Chemicals	100mg	EUR 800
Description: 871700-65-1

Trametinib (GSK1120212)
A3018-200	ApexBio	200 mg	EUR 153.6
Description: MAPK Signaling|MEK1/2

Trametinib (GSK1120212)
A3018-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 44
Description: MAPK Signaling|MEK1/2

Trametinib (GSK1120212)
A3018-50	ApexBio	50 mg	EUR 76.8
Description: MAPK Signaling|MEK1/2

Trametinib (GSK1120212)
A3018-500	ApexBio	500 mg	EUR 324
Description: MAPK Signaling|MEK1/2

Trametinib (GSK1120212)
A3018-S	ApexBio	Evaluation Sample	EUR 24
Description: MAPK Signaling|MEK1/2

Trametinib (GSK1120212)
MBS576333-100mg	MyBiosource	100mg	EUR 180

Trametinib (GSK1120212)
MBS576333-10mg	MyBiosource	10mg	EUR 145

Trametinib (GSK1120212)
MBS576333-200mg	MyBiosource	200mg	EUR 210

Trametinib (GSK1120212)
MBS576333-50mg	MyBiosource	50mg	EUR 155

Trametinib (GSK1120212)
MBS576333-5mg	MyBiosource	5mg	EUR 130

RIPA Lysis Buffer (Strong)
abx090624-100l	Abbexa	100 µl	EUR 150

RIPA Lysis Buffer (Strong)
abx090624-100ml	Abbexa	100 ml	EUR 260.4

RIPA Lysis Buffer (Strong)
abx090624-1ml	Abbexa	1 ml	Ask for price

RIPA Lysis Buffer (Strong)
abx090624-200l	Abbexa	200 µl	Ask for price

RIPA Lysis Buffer (Strong)
E-BC-R327-50mL	Elabscience Biotech	50mL	EUR 60

RIPA Lysis Buffer (Strong)
E-BC-R327-each	Elabscience Biotech	each	Ask for price

RIPA Lysis Buffer (Strong)
E-BC-R327-100mL	Elabscience Biotech	100mL	EUR 80

RIPA Lysis Buffer (Strong)
E-BC-R327-20mL	Elabscience Biotech	20mL	EUR 25

Strong RIPA Lysis Buffer
EZPS03-1	Shanghai WSHT Biotechnology	100mL	EUR 15

RIPA Lysis Buffer (Strong)
HY-K1001	MedChemExpress	100 mL	EUR 176.4

RIPA Lysis Buffer (Strong)
MBS355478-100mL	MyBiosource	100mL	EUR 210

RIPA Lysis Buffer (Strong)
MBS355478-5x100mL	MyBiosource	5x100mL	EUR 640

Carbol Fuchsin (ZN,Strong)
S005-125ML	EWC Diagnostics	1 unit	EUR 3.16
Description: Carbol Fuchsin (ZN,Strong)

Carbol Fuchsin (ZN,Strong)
S005-500ML	EWC Diagnostics	1 unit	EUR 10.92
Description: Carbol Fuchsin (ZN,Strong)

Trametinib DMSO solvate
123211	MedKoo Biosciences	10.0mg	EUR 90

Trametinib DMSO solvate
A3887-10	ApexBio	10 mg	EUR 40
Description: MAPK Signaling|MEK1/2

Trametinib DMSO solvate
A3887-100	ApexBio	100 mg	EUR 95.2
Description: MAPK Signaling|MEK1/2

Trametinib DMSO solvate
A3887-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 44
Description: MAPK Signaling|MEK1/2

Trametinib DMSO solvate
A3887-50	ApexBio	50 mg	EUR 64
Description: MAPK Signaling|MEK1/2

Trametinib (DMSO solvate)
HY-10999A	MedChemExpress	100mg	EUR 75.76
Description: Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis[1][2].

Trametinib DMSO solvate
MBS5752199-100mg	MyBiosource	100mg	EUR 180

Trametinib DMSO solvate
MBS5752199-10mg	MyBiosource	10mg	EUR 145

Trametinib DMSO solvate
MBS5752199-200mg	MyBiosource	200mg	EUR 225

Trametinib DMSO solvate
MBS5752199-25mg	MyBiosource	25mg	EUR 145

Trametinib DMSO solvate
MBS5752199-50mg	MyBiosource	50mg	EUR 160

Trametinib (DMSO solvate)
MBS3845880-100mg	MyBiosource	100mg	EUR 425

Trametinib (DMSO solvate)
MBS3845880-10mg	MyBiosource	10mg	EUR 140

Trametinib (DMSO solvate)
MBS3845880-25mg	MyBiosource	25mg	EUR 200

Trametinib (DMSO solvate)
MBS3845880-50mg	MyBiosource	50mg	EUR 275

Trametinib (DMSO solvate)
MBS3845880-5x100mg	MyBiosource	5x100mg	EUR 1910

Trametinib DMSO solvate
MBS3600640-100mg	MyBiosource	100mg	EUR 245

Trametinib DMSO solvate
MBS3600640-10mg	MyBiosource	10mg	EUR 200

Trametinib DMSO solvate
MBS3600640-200mg	MyBiosource	200mg	EUR 290

Trametinib DMSO solvate
MBS3600640-25mg	MyBiosource	25mg	EUR 200

Trametinib DMSO solvate
MBS3600640-50mg	MyBiosource	50mg	EUR 220

Trametinib Impurity-I
T138340	Toronto Research Chemicals	10mg	EUR 800
Description: 1383430-03-2

Trametinib (DMSO Solvate)
T314310	Toronto Research Chemicals	100mg	EUR 800
Description: 1187431-43-1

Trametinib (DMSO solvate)
T5857-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)
T5857-1g	TargetMol Chemicals	1g	Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)
T5857-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)
T5857-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)
T5857-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Trametinib (DMSO solvate)

WB Stripping Solution Strong
05677-65	NACALAI TESQUE	500ML	EUR 142.8

OOMC00081-10MG - Trametinib
OOMC00081-10MG	Aviva Systems Biology	10mg	EUR 59

OOMC00081-50MG - Trametinib
OOMC00081-50MG	Aviva Systems Biology	50mg	EUR 199

Trametinib [CAS# 871700-17-3]
T-8123	LC LABORATORIES	10 mg	EUR 38

Trametinib dimethyl sulfoxide
414033	MedKoo Biosciences	25.0mg	EUR 228

Clear Seal Strong Sheet (100)
MAAB-0685	Westburg	each	EUR 255.61

HiDecal (Strong decalcifying solution)
R085-500ML	EWC Diagnostics	1 unit	EUR 21.95
Description: HiDecal (Strong decalcifying solution)

Arg-SEC Mobile Phase(Strong)
17000-51	NACALAI TESQUE	1L	EUR 105

Pierce Seal Strong Roll - 1ROLL
PCR0636	Scientific Laboratory Supplies	1ROLL	EUR 1314.9

GSK1120212 (JTP-74057, Trametinib)
MBS384815-100mg	MyBiosource	100mg	EUR 210

GSK1120212 (JTP-74057, Trametinib)
MBS384815-10mg	MyBiosource	10mg	EUR 145

GSK1120212 (JTP-74057, Trametinib)
MBS384815-1mLinDMSO	MyBiosource	1mL(inDMSO)	EUR 145

GSK1120212 (JTP-74057, Trametinib)
MBS384815-50mg	MyBiosource	50mg	EUR 170

GSK1120212 (JTP-74057, Trametinib)
MBS384815-5mg	MyBiosource	5mg	EUR 130

Pierce Seal Strong Sheets - PK100
PCR0632	Scientific Laboratory Supplies	PK100	EUR 140.4

Tissue/cell lysis buffer（Strong)
RM17482	Abclonal	10mL	EUR 53.14

Modified Duncan Strong (DS) Medium
M1237-500G	EWC Diagnostics	1 unit	EUR 80.55
Description: Modified Duncan Strong (DS) Medium

replacement tip Kit strong thick
INS2090	Scientific Laboratory Supplies	EACH	EUR 8.33

Pierce Seal Strong Roll610mX78mm - 1ROLL
PCR0628	Scientific Laboratory Supplies	1ROLL	EUR 1104.3

Western Stripping buffer (Strong alkaline)
EZWB03-1-100mL	Shanghai WSHT Biotechnology	100mL	EUR 9.6

Western Stripping buffer (Strong alkaline)
EZWB03-1-500mL	Shanghai WSHT Biotechnology	500mL	EUR 28.8

Trametinib, DMSO Solvate [CAS# 1187431-43-1]
T-8188	LC LABORATORIES	10 mg	EUR 38

Tweezers Fine Strong CF Tips - EACH
INS5058	Scientific Laboratory Supplies	EACH	EUR 37.6

Tweezers Flat Strong CF Tips - EACH
INS5100	Scientific Laboratory Supplies	EACH	EUR 43.92

PCR Foil Seal Strong Sheets - PK100
PCR0528	Scientific Laboratory Supplies	PK100	EUR 211.95

EP Reagent Sodium Hypochlorite Sol. Strong - 500ML
10816005	Scientific Laboratory Supplies	500ML	EUR 136.35

Pierce Seal Strong Sample Roll - 1ROLL
PCR0630	Scientific Laboratory Supplies	1ROLL	EUR 59.63

replacement tip Kit strong thick - EACH
INS2058	Scientific Laboratory Supplies	EACH	EUR 11.65

replacement tip Kit strong point - EACH
INS2094	Scientific Laboratory Supplies	EACH	EUR 11.65

Modified Duncan Strong (DS) HiVeg Medium
MV1237-500G	EWC Diagnostics	1 unit	EUR 80.55
Description: Modified Duncan Strong (DS) HiVeg Medium

anti PAI-1 (very strong for human)
MBS480230-1mg	MyBiosource	1mg	EUR 790

anti PAI-1 (very strong for human)
MBS480230-5x1mg	MyBiosource	5x1mg	EUR 3315

Strong RIPA Lysis Buffer (without inhibitors)
EZPS03-2	Shanghai WSHT Biotechnology	100mL	EUR 12.6

EP Reagent Sodium Hydroxide Sol. Strong - 1L
1081404	Scientific Laboratory Supplies	1L	EUR 191.7

Tweezers, Rubis Sturdy, Strong Pointed, 115mm, 4.5€
25046-1	Polysciences Europe GmbH	1EA	EUR 52.92

Silver Protein for Histology, Strong (not certified)
25108-25	Polysciences Europe GmbH	25g	EUR 479.52
Description: 9015-51-4

Silver Protein for Histology, Strong (not certified)
25108-5	Polysciences Europe GmbH	5g	EUR 125.28
Description: 9015-51-4

Magnetic Base Support Z w/ Strong Magnet - 34.5mm
M-R-1013161	MiTeGen	1 UNIT	EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 34.5mm

Magnetic Base Support Z w/ Strong Magnet - 27.5mm
M-R-1015229	MiTeGen	1 UNIT	EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 27.5mm

Seralite SRC-120, Strong Acid Cation Exchange Resin
14891	Sisco Laboratories	500 Gms	EUR 3.76
Description: Part A

Seralite SRA-400, Strong Basic Anion Exchange Resin
52228	Sisco Laboratories	500 Gms	EUR 5.82
Description: Part A

UCW5072, Low TOC Strong Base Anion Resin, OH Form
50240-1	Polysciences Europe GmbH	1000ml	EUR 213.84

UCW5072, Low TOC Strong Base Anion Resin, OH Form
50240-250	Polysciences Europe GmbH	250ml	EUR 69.12

A510, Type 2 Macroporous Strong Base Rsin, Chloride Form
50223-1	Polysciences Europe GmbH	1000ml	EUR 160.92
Description: 69011-15-0

DiagAg™ Strong Anion Exchange Agarose Particles, 40 μm
DAG-CL23-08	Creative Diagnostics	25 mL	EUR 920

A510, Type 2 Macroporous Strong Base Resin, Chloride Form
50223-250	Polysciences Europe GmbH	250ml	EUR 52.92
Description: 69011-15-0

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form
50218-1	Polysciences Europe GmbH	1000ml	EUR 160.92
Description: 9052-45-3

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form
50218-250	Polysciences Europe GmbH	250ml	EUR 52.92
Description: 9052-45-3

Optically clear sealing film for qPCR, Strong Bond, for PP plates, 100/pk
MS1000-PCR2	Benchmark Scientific	1 each	EUR 149.35

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 24-45 µm
DAG-YS23-27	Creative Diagnostics	25 mL	EUR 680

 

A prognosis-predictive nomogram of ovarian most cancers with two immune-related genes: CDC20B and PNPLA5

 

Ovarian carcinoma (OV) is probably going one of the lethal gynecological malignancies globally, and the final 5-year survival cost of OV was 47% in 2018 based mostly on American info. To increase the survival cost of victims with OV, many researchers have sought to determine biomarkers that act as every prognosis-predictive markers and treatment targets.

 

Nonetheless, most of these have not been acceptable for scientific software program. The present analysis geared towards establishing a predictive prognostic nomogram of OV using the genes acknowledged by combining The Most cancers Genome Atlas (TCGA) dataset for OV with the immune score calculated by the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression info algorithm. Firstly, the algorithm was used to calculate the immune score of victims with OV inside the TCGA-OV dataset.

 

Secondly, differentially expressed genes (DEGs) between excessive and low immune score tissues have been acknowledged, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis was carried out to predict the options of these DEGs. Thirdly, univariate, multivariate and Lasso Cox’s regression analyses have been carried out step-by-step, and 6 prognosis-relatedDEGs have been acknowledged.

 

Then, Kaplan-Myer survival curves have been generated for these genes and validated by evaluating their expression ranges to further slender the fluctuate of DEGs and to calculate the hazard score. Two genes have been acknowledged, cell division cycle 20B and patatin-like phospholipase space containing 5, which have been every confirmed to have elevated expression ranges in OV tissues and to be significantly associated to the prognosis of OV.

 

Subsequent, a nomogram was created using these two genes and age, and using the receiver working attribute (ROC) curve and calibration curve, the effectiveness of the nomogram was validated. Lastly, an exterior validation was carried out for this nomogram. The ROC confirmed that the areas beneath the curve (AUCs) of the 3- and 5-year whole survival predictions for the nomogram have been 0.678 and 0.62, respectively. Moreover, the ROC of the outside validation model confirmed that the AUCs of the 3- and 5-year have been 0.699 and 0.643, respectively, demonstrating the effectiveness of the generated nomogram. In conclusion, the present analysis has acknowledged two immune-related genes as biomarkers that reliably predict whole survival in OV. These biomarkers can also be potential molecular targets of immune treatment to cope with victims with OV.

 

RIPA Lysis Buffer (Strong)
HY-K1001	MedChemExpress	100 mL	EUR 176.4

RIPA Lysis Buffer (Strong)
MBS355478-100mL	MyBiosource	100mL	EUR 210

RIPA Lysis Buffer (Strong)
MBS355478-5x100mL	MyBiosource	5x100mL	EUR 640

Carbol Fuchsin (ZN,Strong)
S005-125ML	EWC Diagnostics	1 unit	EUR 3.16
Description: Carbol Fuchsin (ZN,Strong)

Carbol Fuchsin (ZN,Strong)
S005-500ML	EWC Diagnostics	1 unit	EUR 10.92
Description: Carbol Fuchsin (ZN,Strong)

WB Stripping Solution Strong
05677-65	NACALAI TESQUE	500ML	EUR 142.8

Clear Seal Strong Sheet (100)
MAAB-0685	Westburg	each	EUR 255.61

HiDecal (Strong decalcifying solution)
R085-500ML	EWC Diagnostics	1 unit	EUR 21.95
Description: HiDecal (Strong decalcifying solution)

Arg-SEC Mobile Phase(Strong)
17000-51	NACALAI TESQUE	1L	EUR 105

Pierce Seal Strong Roll - 1ROLL
PCR0636	Scientific Laboratory Supplies	1ROLL	EUR 1314.9

Pierce Seal Strong Sheets - PK100
PCR0632	Scientific Laboratory Supplies	PK100	EUR 140.4

Tissue/cell lysis buffer（Strong)
RM17482	Abclonal	10mL	EUR 53.14

Modified Duncan Strong (DS) Medium
M1237-500G	EWC Diagnostics	1 unit	EUR 80.55
Description: Modified Duncan Strong (DS) Medium

replacement tip Kit strong thick
INS2090	Scientific Laboratory Supplies	EACH	EUR 8.33

Pierce Seal Strong Roll610mX78mm - 1ROLL
PCR0628	Scientific Laboratory Supplies	1ROLL	EUR 1104.3

Western Stripping buffer (Strong alkaline)
EZWB03-1-100mL	Shanghai WSHT Biotechnology	100mL	EUR 9.6

Western Stripping buffer (Strong alkaline)
EZWB03-1-500mL	Shanghai WSHT Biotechnology	500mL	EUR 28.8

Tweezers Fine Strong CF Tips - EACH
INS5058	Scientific Laboratory Supplies	EACH	EUR 37.6

Tweezers Flat Strong CF Tips - EACH
INS5100	Scientific Laboratory Supplies	EACH	EUR 43.92

PCR Foil Seal Strong Sheets - PK100
PCR0528	Scientific Laboratory Supplies	PK100	EUR 211.95

EP Reagent Sodium Hypochlorite Sol. Strong - 500ML
10816005	Scientific Laboratory Supplies	500ML	EUR 136.35

Pierce Seal Strong Sample Roll - 1ROLL
PCR0630	Scientific Laboratory Supplies	1ROLL	EUR 59.63

replacement tip Kit strong thick - EACH
INS2058	Scientific Laboratory Supplies	EACH	EUR 11.65

replacement tip Kit strong point - EACH
INS2094	Scientific Laboratory Supplies	EACH	EUR 11.65

Modified Duncan Strong (DS) HiVeg Medium
MV1237-500G	EWC Diagnostics	1 unit	EUR 80.55
Description: Modified Duncan Strong (DS) HiVeg Medium

anti PAI-1 (very strong for human)
MBS480230-1mg	MyBiosource	1mg	EUR 790

anti PAI-1 (very strong for human)
MBS480230-5x1mg	MyBiosource	5x1mg	EUR 3315

Strong RIPA Lysis Buffer (without inhibitors)
EZPS03-2	Shanghai WSHT Biotechnology	100mL	EUR 12.6

EP Reagent Sodium Hydroxide Sol. Strong - 1L
1081404	Scientific Laboratory Supplies	1L	EUR 191.7

Tweezers, Rubis Sturdy, Strong Pointed, 115mm, 4.5€
25046-1	Polysciences Europe GmbH	1EA	EUR 52.92

Silver Protein for Histology, Strong (not certified)
25108-25	Polysciences Europe GmbH	25g	EUR 479.52
Description: 9015-51-4

Silver Protein for Histology, Strong (not certified)
25108-5	Polysciences Europe GmbH	5g	EUR 125.28
Description: 9015-51-4

Magnetic Base Support Z w/ Strong Magnet - 34.5mm
M-R-1013161	MiTeGen	1 UNIT	EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 34.5mm

Magnetic Base Support Z w/ Strong Magnet - 27.5mm
M-R-1015229	MiTeGen	1 UNIT	EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 27.5mm

Seralite SRC-120, Strong Acid Cation Exchange Resin
14891	Sisco Laboratories	500 Gms	EUR 3.76
Description: Part A

Seralite SRA-400, Strong Basic Anion Exchange Resin
52228	Sisco Laboratories	500 Gms	EUR 5.82
Description: Part A

UCW5072, Low TOC Strong Base Anion Resin, OH Form
50240-1	Polysciences Europe GmbH	1000ml	EUR 213.84

UCW5072, Low TOC Strong Base Anion Resin, OH Form
50240-250	Polysciences Europe GmbH	250ml	EUR 69.12

A510, Type 2 Macroporous Strong Base Rsin, Chloride Form
50223-1	Polysciences Europe GmbH	1000ml	EUR 160.92
Description: 69011-15-0

DiagAg™ Strong Anion Exchange Agarose Particles, 40 μm
DAG-CL23-08	Creative Diagnostics	25 mL	EUR 920

A510, Type 2 Macroporous Strong Base Resin, Chloride Form
50223-250	Polysciences Europe GmbH	250ml	EUR 52.92
Description: 69011-15-0

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form
50218-1	Polysciences Europe GmbH	1000ml	EUR 160.92
Description: 9052-45-3

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form
50218-250	Polysciences Europe GmbH	250ml	EUR 52.92
Description: 9052-45-3

Optically clear sealing film for qPCR, Strong Bond, for PP plates, 100/pk
MS1000-PCR2	Benchmark Scientific	1 each	EUR 149.35

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 24-45 µm
DAG-YS23-27	Creative Diagnostics	25 mL	EUR 680

Rapamycin
1568-5	Biovision	each	EUR 339.6

Rapamycin
1568-50	Biovision	each	EUR 1396.8

Rapamycin
22470-54	NACALAI TESQUE	100ug	EUR 175.95
Description: 53123-88-9

Rapamycin
27062	BPS Bioscience	50 mg	EUR 135
Description: Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50 pM).

Rapamycin
30037-94	NACALAI TESQUE	100UG	EUR 138.6

Rapamycin
abx076788-100l	Abbexa	100 µl	EUR 118.75

Rapamycin
abx076788-1ml	Abbexa	1 ml	Ask for price

Rapamycin
abx076788-200l	Abbexa	200 µl	EUR 300

Rapamycin
20-abx076788	Abbexa	Ask for price Ask for price	5 mg 25 mg

Rapamycin
20-abx185560	Abbexa	Ask for price Ask for price	5 mg 25 mg

Rapamycin
HY-10219	MedChemExpress	200mg	EUR 272.73
Description: Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

Rapamycin
E1B1842	EnoGene	1mg	EUR 60

Rapamycin
G613	ABM	100 mg	EUR 800

Rapamycin
GA7417	Glentham Life Sciences	5mg	EUR 181.03

Rapamycin
GA7417-100	Glentham Life Sciences	100	EUR 197.7

Rapamycin
GA7417-100MG	Glentham Life Sciences	100 mg	EUR 274.8

Rapamycin
GA7417-25	Glentham Life Sciences	25	EUR 63.3

Rapamycin
GA7417-25MG	Glentham Life Sciences	25 mg	EUR 112.8

Rapamycin
GA7417-5	Glentham Life Sciences	5	EUR 23.8

Rapamycin
GA7417-50	Glentham Life Sciences	50	EUR 118.7

Rapamycin
GA7417-50MG	Glentham Life Sciences	50 mg	EUR 180

Rapamycin
GA7417-5MG	Glentham Life Sciences	5 mg	EUR 64.8

Rapamycin
MBS132175-100mg	MyBiosource	100mg	EUR 1065

Rapamycin
MBS132175-500mg	MyBiosource	500mg	EUR 2775

Rapamycin
MBS515013-100mg	MyBiosource	100mg	EUR 665

Rapamycin
MBS515013-20mg	MyBiosource	20mg	EUR 320

Rapamycin
MBS515013-5x100mg	MyBiosource	5x100mg	EUR 2740

Rapamycin
MBS3604884-100mg	MyBiosource	100mg	EUR 210

Rapamycin
MBS3604884-200mg	MyBiosource	200mg	EUR 240

Rapamycin
MBS3604884-50mg	MyBiosource	50mg	EUR 195

Rapamycin
MBS3604884-5x200mg	MyBiosource	5x200mg	EUR 760

Rapamycin
MBS407517-100mg	MyBiosource	100mg	EUR 175

Rapamycin
MBS407517-1g	MyBiosource	1g	EUR 450

Rapamycin
MBS407517-5x100mg	MyBiosource	5x100mg	EUR 730

Rapamycin
MBS407517-5x1g	MyBiosource	5x1g	EUR 1970

Rapamycin
MBS696245-10mg	MyBiosource	10mg	EUR 235

Rapamycin
MBS696245-1mg	MyBiosource	1mg	EUR 135

Rapamycin
MBS696245-5x10mg	MyBiosource	5x10mg	EUR 1005

Rapamycin
MBS8579821-1mg	MyBiosource	1mg	EUR 155

Rapamycin
MBS8579821-5x1mg	MyBiosource	5x1mg	EUR 555

Rapamycin
MBS807957-25mg	MyBiosource	25mg	EUR 450

Rapamycin
MBS807957-5mg	MyBiosource	5mg	EUR 260

Rapamycin
MBS807957-5x25mg	MyBiosource	5x25mg	EUR 1770

Rapamycin
MBS807957-5x5mg	MyBiosource	5x5mg	EUR 905

Rapamycin
T1537-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Rapamycin

Rapamycin
T1537-1g	TargetMol Chemicals	1g	Ask for price
Description: Rapamycin

Rapamycin
T1537-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Rapamycin

Rapamycin
T1537-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Rapamycin

Rapamycin
T1537-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Rapamycin

Rapamycin
SIH-212-25MG	Stressmarq	25 mg	EUR 276

Rapamycin
SIH-212-5MG	Stressmarq	5 mg	EUR 110.4

Rapamycin
R001-10MG	TOKU-E	10 mg	EUR 152.4
Description: 53123-88-9

Rapamycin
R001-25MG	TOKU-E	25 mg	EUR 191.52
Description: 53123-88-9

Rapamycin
tlrl-rap-5	InvivoGen FR	5 x 5 mg	EUR 248.85

Rapamycin, 100mg
R5312	ACTGene	100mg	EUR 607.18

Rapamycin, 100mg
R5312-100mg	ACTGene	each	EUR 902.4

Rapamycin, >99%
BC082-050	GenDepot	50mg	EUR 142

Rapamycin, >99%
BC082-100	GenDepot	100mg	EUR 176

Rapamycin, >99%
BC082-250	GenDepot	250mg	EUR 250

Rapamycin, >99%
BC082-500	GenDepot	500mg	EUR 385

Rapamycin (>85%)
R124000	Toronto Research Chemicals	100mg	EUR 80
Description: 53123-88-9

Rapamycin (GMP)
HY-10219G	MedChemExpress	Get quote	Ask for price
Description: Rapamycin (Sirolimus) (GMP) is Rapamycin (HY-10219) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin is a potent and specific mTOR inhibitor[1][2][3].

Rapamycin-13C,d3
HY-10219S1	MedChemExpress	Get quote	Ask for price
Description: Rapamycin-13C,d3 (Sirolimus-13C,d3; AY-22989-13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219)[1]. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[2]. Rapamycin is an autophagy activator, an immunosuppressant[3].

Rapamycin-13C, D3
ESS0567-5mg	ESSchemco	5 mg	EUR 840
Description: Sirolimus-13C, D3

Rapamycin-d3
HY-10219S	MedChemExpress	1 mg	EUR 119.05
Description: Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

Rapamycin-D3
ESS0404-5mg	ESSchemco	5 mg	EUR 630
Description: Sirolimus-D3

Seco Rapamycin
HY-19555	MedChemExpress	50mg	EUR 2704.8
Description: Seco Rapamycin (Secorapamycin A) is the ring-opened product of Rapamycin. Seco-rapamycin is reported not to affect the mTOR function[1].

Seco Rapamycin
MBS5799522-5mg	MyBiosource	5(mg	EUR 915

Seco Rapamycin
MBS5799522-5x5mg	MyBiosource	5x5(mg	EUR 3970

Rapamycin-d3
T12691-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Rapamycin-d3

Rapamycin-d3
T12691-1g	TargetMol Chemicals	1g	Ask for price
Description: Rapamycin-d3

Rapamycin-d3
T12691-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Rapamycin-d3

Rapamycin-d3
T12691-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Rapamycin-d3

Rapamycin-d3
T12691-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Rapamycin-d3

Rapamycin, 10mg
R5312-10mg	ACTGene	each	EUR 244.8

Seco Rapamycin
T38963-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Seco Rapamycin

Seco Rapamycin
T38963-1g	TargetMol Chemicals	1g	Ask for price
Description: Seco Rapamycin

Seco Rapamycin
T38963-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Seco Rapamycin

Seco Rapamycin
T38963-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Seco Rapamycin

Seco Rapamycin
T38963-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Seco Rapamycin

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, Low Capacity
DAG-YS23-28	Creative Diagnostics	25 mL	EUR 680

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, High Capacity
DAG-YS23-29	Creative Diagnostics	25 mL	EUR 680

Sirolimus (Rapamycin)
100766	MedKoo Biosciences	25.0mg	EUR 90

Rapamycin (Sirolimus)
A8167-100	ApexBio	100 mg	EUR 154.4
Description: PI3K/Akt/mTOR Signaling|mTOR

Rapamycin (Sirolimus)
A8167-25	ApexBio	25 mg	EUR 81.6
Description: PI3K/Akt/mTOR Signaling|mTOR

Rapamycin (Sirolimus)
A8167-5	ApexBio	5 mg	EUR 40
Description: PI3K/Akt/mTOR Signaling|mTOR

Rapamycin (Sirolimus)
A8167-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 48
Description: PI3K/Akt/mTOR Signaling|mTOR

Rapamycin (Sirolimus)
A8167-S	ApexBio	Evaluation Sample	EUR 24
Description: PI3K/Akt/mTOR Signaling|mTOR

Rapamycin (Sirolimus)
E1KS1039	EnoGene	50mg	EUR 120

Rapamycin (Sirolimus)
MBS386035-100mg	MyBiosource	100mg	EUR 160

Rapamycin (Sirolimus)
MBS386035-1mLinDMSO	MyBiosource	1mL(inDMSO)	EUR 140

Rapamycin (Sirolimus)
MBS386035-50mg	MyBiosource	50mg	EUR 145

Rapamycin (Sirolimus)
MBS386035-5mg	MyBiosource	5mg	EUR 130

Rapamycin (Sirolimus)
MBS386035-5x100mg	MyBiosource	5x100mg	EUR 715

Rapamycin (Sirolimus)
MBS575148-100mg	MyBiosource	100mg	EUR 155

Rapamycin (Sirolimus)
MBS575148-200mg	MyBiosource	200mg	EUR 185

Rapamycin (Sirolimus)
MBS575148-25mg	MyBiosource	25mg	EUR 135

Rapamycin (Sirolimus)
MBS575148-500mg	MyBiosource	500mg	EUR 260

Rapamycin (Sirolimus)
MBS575148-50mg	MyBiosource	50mg	EUR 145

Rapamycin (Sirolimus)
MBS8506576-50mg	MyBiosource	50mg	EUR 210

Rapamycin (Sirolimus)
MBS8506576-5x50mg	MyBiosource	5x50mg	EUR 800

Foil seals, strong bonding for cold storage (-200 to 110°C) and DMSO, for PP plates, 100/pk
MS1000-F2	Benchmark Scientific	1 each	EUR 149.35

EZSolution? Rapamycin
1746-5	Biovision	each	EUR 326.4

Estrogen receptor (ER) IHC control with strong, moderate, low/negative expressersHumanBreastBreastIHC control
ERC083	Pantomics	1.5mm	EUR 50

Rapamycin analog-2
HY-153511	MedChemExpress	Get quote	Ask for price
Description: Rapamycin analog-2 (compound A) is a Rapamycin analog[1].

rapamycin derivative 1
R454500	Toronto Research Chemicals	25mg	EUR 1800

rapamycin derivative 2
R574880	Toronto Research Chemicals	100mg	EUR 9200

TOR | Target of rapamycin
AS12-2608	Agrisera AB	50 µg	EUR 302

OOMC00007-10MG - Rapamycin
OOMC00007-10MG	Aviva Systems Biology	10mg	EUR 69

OOMC00007-50MG - Rapamycin
OOMC00007-50MG	Aviva Systems Biology	50mg	EUR 249

Rapamycin-31,42-Diester Impurity
R124015	Toronto Research Chemicals	50mg	EUR 1938

Rapamycin [CAS# 53123-88-9]
R-5000	LC LABORATORIES	50 mg	EUR 48

42-O-Formyl Rapamycin
ESS0554-5mg	ESSchemco	5 mg	EUR 525
Description: Everolimus EP Impurity E

33-O-Formyl Rapamycin
F699010	Toronto Research Chemicals	10mg	EUR 1728

7-O-Demethyl rapamycin
HY-123691	MedChemExpress	Get quote	Ask for price
Description: 7-O-Demethyl rapamycin, a derivative of Rapamycin (HY-10219), has antifungal activity and immunosuppressant properties. 7-O-Demethyl rapamycin has useful tumor cell growth-inhibiting activity[1].

Seco Rapamycin ethyl ester
HY-133770	MedChemExpress	10 mg	EUR 2380.99
Description: Seco Rapamycin ethyl ester is an open-ring metabolite of Rapamycin derivative. Seco-rapamycin is reported not to affect the mTOR function[1].

Seco Rapamycin (sodium salt)
HY-19555A	MedChemExpress	1mg	EUR 2077.95
Description: Seco Rapamycin sodium salt is the ring-opened product of Rapamycin. Seco-rapamycin is reported not to affect the mTOR function.

7-O-Demethyl rapamycin
MBS5775613-10mg	MyBiosource	10mg	EUR 2020

7-O-Demethyl rapamycin
MBS5775613-25mg	MyBiosource	25mg	EUR 1995

7-O-Demethyl rapamycin
MBS5775613-5mg	MyBiosource	5(mg	EUR 1235

Seco Rapamycin sodium salt
MBS5756112-25mg	MyBiosource	25mg	EUR 1405

Seco Rapamycin sodium salt
MBS5756112-50mg	MyBiosource	50mg	EUR 2410

Seco Rapamycin sodium salt
MBS5756112-5x50mg	MyBiosource	5x50mg	EUR 10695

Seco Rapamycin sodium salt
MBS3602049-10mg	MyBiosource	10mg	EUR 655

Seco Rapamycin sodium salt
MBS3602049-25mg	MyBiosource	25mg	EUR 1075

Seco Rapamycin sodium salt
MBS3602049-50mg	MyBiosource	50mg	EUR 1630

Seco Rapamycin sodium salt
MBS3602049-5mg	MyBiosource	5mg	EUR 465

Seco Rapamycin sodium salt
MBS3602049-5x50mg	MyBiosource	5x50mg	EUR 7015

7-O-Demethyl Rapamycin
MBS6080732-25mg	MyBiosource	2.5(mg	EUR 665

7-O-Demethyl Rapamycin
MBS6080732-5x25mg	MyBiosource	5x2.5mg	EUR 2845

7-O-Demethyl rapamycin
T25882-10mg	TargetMol Chemicals	10mg	Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin
T25882-1g	TargetMol Chemicals	1g	Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin
T25882-1mg	TargetMol Chemicals	1mg	Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin
T25882-50mg	TargetMol Chemicals	50mg	Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin
T25882-5mg	TargetMol Chemicals	5mg	Ask for price
Description: 7-O-Demethyl rapamycin

Seco Rapamycin sodium salt
T19558-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt
T19558-1g	TargetMol Chemicals	1g	Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt
T19558-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt
T19558-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt
T19558-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Seco Rapamycin sodium salt

42-(2-Tetrazolyl)rapamycin
HY-12424A	MedChemExpress	1mg	EUR 311.69
Description: 42-(2-Tetrazolyl)rapamycin is a proagent compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.

42-(2-Tetrazolyl)rapamycin
MBS5752629-50mg	MyBiosource	50mg	EUR 1325

42-(2-Tetrazolyl)rapamycin
MBS5752629-5x50mg	MyBiosource	5x50mg	EUR 5800

42-(2-Tetrazolyl)rapamycin
MBS3845824-100mg	MyBiosource	100mg	EUR 3100

42-(2-Tetrazolyl)rapamycin
MBS3845824-10mg	MyBiosource	10mg	EUR 575