Methylation Standing of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Thoughts

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prionics

The Affiliation between Periodontitis and Human Colorectal Most cancers: Genetic and Pathogenic Linkage

Periodontitis has been associated to an elevated menace of and mortality associated to human colorectal most cancers (CRC). Current proof attributes such an affiliation to the direct and indirect outcomes of virulence parts belonging to periodontal pathogens, to inflammatory mediators and to genetic parts.

 

The objectives of the analysis have been to guage the existence of a genetic linkage between periodontitis and human CRC, to determine genes thought-about predominant in such a linkage, thus named chief genes, and to search out out pathogenic mechanisms related to the merchandise of chief genes.

 

Genes linking periodontitis and CRC have been acknowledged and labeled in order of predominance, by an experimental investigation, carried out by the use of laptop computer simulation, utilizing the chief gene methodology.

 

Pathogenic mechanisms relating to chief genes have been determined by cross-search databases. Of the 83 genes linking periodontitis and CRC, 12 have been labeled as chief genes and have been pathogenically implicated in cell cycle regulation and throughout the immune-inflammatory response. The current outcomes, obtained by the use of laptop computer simulation and requiring further validation, help the existence of a genetic linkage between periodontitis and CRC. Cell cycle dysregulation and the alteration of the immuno-inflammatory response symbolize the pathogenic mechanisms related to the merchandise of chief genes.

 

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EOSIN METHYLENE BLUE AGAR

E05-102-2Kg 2 Kg
EUR 264

EOSIN METHYLENE BLUE AGAR

E05-102-500g 500 g
EUR 108

EOSIN METHYLENE BLUE AGAR,LEVINE

E05-103-10kg 10 kg
EUR 1035

EOSIN METHYLENE BLUE AGAR,LEVINE

E05-103-2kg 2kg
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EOSIN METHYLENE BLUE AGAR,LEVINE

E05-103-500g 500 g
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E05-104-500g 500 g Ask for price

ETHYL VIOLET AZIDE BROTH

E05-105-10kg 10 kg
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ETHYL VIOLET AZIDE BROTH

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E05-107-10kg 10 kg
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E05-107-2kg 2kg
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EUGONIC BROTH

E05-107-500g 500 g
EUR 110

EC MEDIUM, MODIFIED

E05-108-10kg 10 kg
EUR 858

EC MEDIUM, MODIFIED

E05-108-2Kg 2 Kg
EUR 226

EC MEDIUM, MODIFIED

E05-108-500g 500 g
EUR 98

EXTRACT BROTH

E05-109-10kg 10 kg
EUR 50

EXTRACT BROTH

E05-109-2kg 2kg
EUR 50

EXTRACT BROTH

E05-109-500g 500 g
EUR 50

ENDO AGAR

E05-110-10kg 10 kg
EUR 2381

ENDO AGAR

E05-110-2Kg 2 Kg
EUR 557

ENDO AGAR

E05-110-500g 500 g
EUR 188

Porcine Malondialdehyde, MDA ELISA Kit

E0597p 96 Tests
EUR 928

Mouse advanced glycation end products, AGEs ELISA Kit

E0263m 96 Tests
EUR 678

MB protein (His tag)

80R-1634 100 ug
EUR 397
Description: Purified recombinant Human MB protein

MAP1LC3B protein (His tag)

80R-1635 100 ug
EUR 349
Description: Purified recombinant Human MAP1LC3B protein

RAB7A protein (His tag)

80R-1636 100 ug
EUR 305
Description: Purified recombinant Human RAB7A protein

Ecotin protein (His tag)

80R-1637 50 ug
EUR 305
Description: Purified recombinant E.coli Ecotin protein

AIF1L protein (His tag)

80R-1638 100 ug
EUR 305
Description: Purified recombinant Human AIF1L protein

AK4 protein (His tag)

80R-1639 100 ug
EUR 305
Description: Purified recombinant Human AK4 protein

BDH2 protein (His tag)

80R-1640 100 ug
EUR 305
Description: Purified recombinant Human BDH2 protein

BPNT1 protein (His tag)

80R-1641 50 ug
EUR 305
Description: Purified recombinant Human BPNT1 protein

DCUN1D1 protein (His tag)

80R-1642 100 ug
EUR 305
Description: Purified recombinant Human DCUN1D1 protein

GABARAPL2 protein (His tag)

80R-1643 50 ug
EUR 397
Description: Purified recombinant Human GABARAPL2 protein

GCA protein (His tag)

80R-1644 50 ug
EUR 397
Description: Purified recombinant Human GCA protein

GGCT protein (His tag)

80R-1645 100 ug
EUR 305
Description: Purified recombinant Human GGCT protein

GRAP2 protein (His tag)

80R-1646 50 ug
EUR 397
Description: Purified recombinant Human GRAP2 protein

NME3 protein (His tag)

80R-1647 100 ug
EUR 305
Description: Purified recombinant Human NME3 protein

NUDT2 protein (His tag)

80R-1648 100 ug
EUR 305
Description: Purified recombinant Human NUDT2 protein

RAP1B protein (His tag)

80R-1649 50 ug
EUR 397
Description: Purified recombinant Human RAP1B protein

TXNL1 protein (His tag)

80R-1650 100 ug
EUR 397
Description: Purified recombinant Human TXNL1 protein

PFDN4 protein (His tag)

80R-1651 50 ug
EUR 397
Description: Purified recombinant Human PFDN4 protein

UBE2K protein (His tag)

80R-1652 50 ug
EUR 397
Description: Purified recombinant Human UBE2K protein

NCALD protein (His tag)

80R-1653 100 ug
EUR 305
Description: Purified recombinant Human NCALD protein

DDIT4 protein (His tag)

80R-1654 50 ug
EUR 397
Description: Purified recombinant Human DDIT4 protein

TFAM protein (His tag)

80R-1655 10 ug
EUR 305
Description: Purified recombinant Human TFAM protein

TAF9 protein (His tag)

80R-1656 100 ug
EUR 305
Description: Purified recombinant Human TAF9 protein

SUGT1 protein (His tag)

80R-1657 100 ug
EUR 305
Description: Purified recombinant Human SUGT1 protein

RAB1A protein (His tag)

80R-1658 50 ug
EUR 305
Description: Purified recombinant Human RAB1A protein

PPP3R1 protein (His tag)

80R-1659 100 ug
EUR 305
Description: Purified recombinant Human PPP3R1 protein

EIF1AY protein (His tag)

80R-1660 50 ug
EUR 397
Description: Purified recombinant Human EIF1AY protein

ATG5 protein (His tag)

80R-1661 50 ug
EUR 305
Description: Purified recombinant Human ATG5 protein

FADH1 protein (His tag)

80R-1662 100 ug
EUR 305
Description: Purified recombinant Human FADH1 protein

PEF1 protein (His tag)

80R-1663 50 ug
EUR 305
Description: Purified recombinant Human PEF1 protein

MLF1 protein (His tag)

80R-1664 100 ug
EUR 305
Description: Purified recombinant Human MLF1 protein

RAB21 protein (His tag)

80R-1665 50 ug
EUR 397
Description: Purified recombinant Human RAB21 protein

LCN2 protein (His tag)

80R-1666 100 ug
EUR 397
Description: Purified recombinant Human LCN2 protein

CIB2 protein (His tag)

80R-1667 100 ug
EUR 305
Description: Purified recombinant Human CIB2 protein

NMT2 protein (His tag)

80R-1668 100 ug
EUR 305
Description: Purified recombinant Human NMT2 protein

DNAJC19 protein (His tag)

80R-1669 100 ug
EUR 305
Description: Purified recombinant Human DNAJC19 protein

DHFR protein (His tag)

80R-1670 100 ug
EUR 305
Description: Purified recombinant mouse DHFR protein

IMPA2 protein (His tag)

80R-1671 50 ug
EUR 305
Description: Purified recombinant Human IMPA2 protein

BCAS2 protein (His tag)

80R-1672 10 ug
EUR 305
Description: Purified recombinant Human BCAS2 protein

BLNK protein (His tag)

80R-1673 100 ug
EUR 305
Description: Purified recombinant Human BLNK protein

CCL3L1 protein (His tag)

80R-1674 100 ug
EUR 305
Description: Purified recombinant Human CCL3L1 protein

CCL20 protein (His tag)

80R-1675 50 ug
EUR 397
Description: Purified recombinant Human CCL20 protein

RAB6B protein (His tag)

80R-1676 100 ug
EUR 305
Description: Purified recombinant Human RAB6B protein

SNRPE protein (His tag)

80R-1677 10 ug
EUR 305
Description: Purified recombinant Human SNRPE protein

SF3B14 protein (His tag)

80R-1678 50 ug
EUR 305
Description: Purified recombinant Human SF3B14 protein

RERG protein (His tag)

80R-1679 50 ug
EUR 397
Description: Purified recombinant Human RERG protein

NUDT3 protein (His tag)

80R-1680 50 ug
EUR 305
Description: Purified recombinant Human NUDT3 protein

MYL9 protein (His tag)

80R-1681 50 ug
EUR 305
Description: Purified recombinant Human MYL9 protein

CAPS protein (His tag)

80R-1682 100 ug
EUR 305
Description: Purified recombinant Human CAPS protein

RPS14 protein (His tag)

80R-1683 10 ug
EUR 305
Description: Purified recombinant Human RPS14 protein

LYPLA2 protein (His tag)

80R-1684 100 ug
EUR 397
Description: Purified recombinant Human LYPLA2 protein

ENOPH1 protein (His tag)

80R-1685 100 ug
EUR 397
Description: Purified recombinant Human ENOPH1 protein

ACYP1 protein (His tag)

80R-1686 100 ug
EUR 305
Description: Purified recombinant Human ACYP1 protein

BATF protein (His tag)

80R-1687 100 ug
EUR 305
Description: Purified recombinant Human BATF protein

CCL14 protein (His tag)

80R-1688 100 ug
EUR 305
Description: Purified recombinant Human CCL14 protein

eFIMC protein (His tag)

80R-1689 100 ug
EUR 305
Description: Purified recombinant E.coli eFIMC protein

ERH protein (His tag)

80R-1690 100 ug
EUR 305
Description: Purified recombinant Human ERH protein

MESDC2 protein (His tag)

80R-1691 100 ug
EUR 397
Description: Purified recombinant Human MESDC2 protein

NUDT16L1 protein (His tag)

80R-1692 100 ug
EUR 397
Description: Purified recombinant Human NUDT16L1 protein

NUDT21 protein (His tag)

80R-1693 100 ug
EUR 305
Description: Purified recombinant Human NUDT21 protein

 

The Have an effect on of Energy Delicate Stress and Agomelatine Treatment on the Expression Stage and Methylation Standing of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Thoughts Constructions

 

Despair is the extreme psychological dysfunction. Earlier analysis counsel that the occasion mechanism of melancholy may be associated to issues of the tryptophan catabolic pathway (TRYCAT). Thus, this analysis investigates the influence of agomelatine remedy on the expression and methylation standing of genes involved in TRYCAT throughout the thoughts and blood of rats uncovered to a persistent delicate stress (CMS).

 

Separate groups of rats have been uncovered to CMS for two or seven weeks; the second group acquired automobile or agomelatine for five weeks. After completion of every stress conditions and remedy, the expression ranges of messenger RNA (mRNA) and protein, along with the methylation standing of promoters, have been measured in peripheral blood mononuclear cells (PBMCs) and in thoughts constructions with utilizing TaqMan Gene Expression Assay,

 

Western blot, and methylation-sensitive high-resolution melting methods. In PBMCs, Kmo mRNA expression elevated throughout the group after CMS, whereas this influence was normalized by agomelatine treatment. In thoughts, KatI and KatII expression modified following CMS publicity.

 

Moreover, CMS decreased the methylation standing of the second Tdo2 promoter throughout the amygdala. Protein expression of Tph1, Tph2, Ido1, and KatII modified throughout the group after CMS and agomelatine administration, most prominently throughout the basal ganglia, cerebral cortex, hippocampus, and amygdala.

 

The outcomes level out that CMS and agomelatine affect the mRNA and protein expression, along with the methylation of promoters of genes involved throughout the tryptophan catabolic pathway.

 

Place of Air Air air pollution and rs10830963 Polymorphism on the Incidence of Sort 2 Diabetes: Tehran Cardiometabolic Genetic Analysis

 

Diabetes mellitus (DM) is taken into consideration one among many predominant properly being factors that are egregiously threatening human life all by way of the world. Numerous epidemiological analysis have examined the connection of a selected matter < 10 μm (PM10) publicity and with form 2 diabetes mellitus (T2DM) prevalence and incidence. Accordingly, the current analysis is a analysis investigating the neutral have an effect on of air air air pollution (AP) and rs10830963 on the incidence of T2DM. A whole number of 2428 adults over 20 years of age participated in a possible cohort (TCGS) all through a 9-year follow-up part.

 

The main target of AP was measured, and the obtained values have been thought-about the indicate diploma in three earlier years given that publicity focus took the oldsters dwelling in that location. The COX regression model was employed to search out out the have an effect on of AP and rs10830963 on the incidence of T2DM in adjustment with covariate parts. Among the many many 392 T2DM, 230 circumstances (58.7%) have been female diabetics, and 162 (41.3%) have been male diabetics. Consistent with the multivariable-adjusted model, publicity to PM10 (per 10 μm/m3), associated to the hazard of T2DM, although solely a borderline (p = 0.07) was found throughout the multivariable model (HR; 1.50, 95% CI; 1-2.32).

 

The rs10830963 was straight associated to the incidence of diabetes, and the GG genotype elevated the T2DM cost by 113% (better than two cases) (HR; 2.134, 95% CI; 1.42-3.21, p ≤ 0.001) and GC elevated it by 65% (HR; 1.65, 95% CI; 1.24-2.21, p ≤ 0.001). Prolonged-term publicity to PM10 was associated with an elevated menace of diabetes. Thus, it is urged that the individuals with variant rs10830963 genotypes fall inside a bunch weak to an elevated menace of T2DM arising from AP.

 

EC MEDIUM WITH MUG
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EC MEDIUM WITH MUG
E05-101-500g 500 g
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EOSIN METHYLENE BLUE AGAR
E05-102-10kg 10 kg
EUR 1034
EOSIN METHYLENE BLUE AGAR
E05-102-2Kg 2 Kg
EUR 264
EOSIN METHYLENE BLUE AGAR
E05-102-500g 500 g
EUR 108
EOSIN METHYLENE BLUE AGAR,LEVINE
E05-103-10kg 10 kg
EUR 1035
EOSIN METHYLENE BLUE AGAR,LEVINE
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EOSIN METHYLENE BLUE AGAR,LEVINE
E05-103-500g 500 g
EUR 108
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E05-104-500g 500 g Ask for price
ETHYL VIOLET AZIDE BROTH
E05-105-10kg 10 kg
EUR 1302
ETHYL VIOLET AZIDE BROTH
E05-105-2kg 2kg
EUR 322
ETHYL VIOLET AZIDE BROTH
E05-105-500g 500 g
EUR 124
EUGONIC AGAR
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EUGONIC AGAR
E05-106-2Kg 2 Kg Ask for price
EUGONIC AGAR
E05-106-500g 500 g Ask for price
EUGONIC BROTH
E05-107-10kg 10 kg
EUR 1058
EUGONIC BROTH
E05-107-2kg 2kg
EUR 269
EUGONIC BROTH
E05-107-500g 500 g
EUR 110
EC MEDIUM, MODIFIED
E05-108-10kg 10 kg
EUR 858
EC MEDIUM, MODIFIED
E05-108-2Kg 2 Kg
EUR 226
EC MEDIUM, MODIFIED
E05-108-500g 500 g
EUR 98
EXTRACT BROTH
E05-109-10kg 10 kg
EUR 50
EXTRACT BROTH
E05-109-2kg 2kg
EUR 50
EXTRACT BROTH
E05-109-500g 500 g
EUR 50
ENDO AGAR
E05-110-10kg 10 kg
EUR 2381
ENDO AGAR
E05-110-2Kg 2 Kg
EUR 557
ENDO AGAR
E05-110-500g 500 g
EUR 188
Porcine Malondialdehyde, MDA ELISA Kit
E0597p 96 Tests
EUR 928
Mouse advanced glycation end products, AGEs ELISA Kit
E0263m 96 Tests
EUR 678
MB protein (His tag)
80R-1634 100 ug
EUR 397
Description: Purified recombinant Human MB protein
MAP1LC3B protein (His tag)
80R-1635 100 ug
EUR 349
Description: Purified recombinant Human MAP1LC3B protein
RAB7A protein (His tag)
80R-1636 100 ug
EUR 305
Description: Purified recombinant Human RAB7A protein
Ecotin protein (His tag)
80R-1637 50 ug
EUR 305
Description: Purified recombinant E.coli Ecotin protein
AIF1L protein (His tag)
80R-1638 100 ug
EUR 305
Description: Purified recombinant Human AIF1L protein
AK4 protein (His tag)
80R-1639 100 ug
EUR 305
Description: Purified recombinant Human AK4 protein
BDH2 protein (His tag)
80R-1640 100 ug
EUR 305
Description: Purified recombinant Human BDH2 protein
BPNT1 protein (His tag)
80R-1641 50 ug
EUR 305
Description: Purified recombinant Human BPNT1 protein
DCUN1D1 protein (His tag)
80R-1642 100 ug
EUR 305
Description: Purified recombinant Human DCUN1D1 protein
GABARAPL2 protein (His tag)
80R-1643 50 ug
EUR 397
Description: Purified recombinant Human GABARAPL2 protein
GCA protein (His tag)
80R-1644 50 ug
EUR 397
Description: Purified recombinant Human GCA protein
GGCT protein (His tag)
80R-1645 100 ug
EUR 305
Description: Purified recombinant Human GGCT protein
GRAP2 protein (His tag)
80R-1646 50 ug
EUR 397
Description: Purified recombinant Human GRAP2 protein
NME3 protein (His tag)
80R-1647 100 ug
EUR 305
Description: Purified recombinant Human NME3 protein
NUDT2 protein (His tag)
80R-1648 100 ug
EUR 305
Description: Purified recombinant Human NUDT2 protein
RAP1B protein (His tag)
80R-1649 50 ug
EUR 397
Description: Purified recombinant Human RAP1B protein
TXNL1 protein (His tag)
80R-1650 100 ug
EUR 397
Description: Purified recombinant Human TXNL1 protein
PFDN4 protein (His tag)
80R-1651 50 ug
EUR 397
Description: Purified recombinant Human PFDN4 protein
UBE2K protein (His tag)
80R-1652 50 ug
EUR 397
Description: Purified recombinant Human UBE2K protein
NCALD protein (His tag)
80R-1653 100 ug
EUR 305
Description: Purified recombinant Human NCALD protein
DDIT4 protein (His tag)
80R-1654 50 ug
EUR 397
Description: Purified recombinant Human DDIT4 protein
TFAM protein (His tag)
80R-1655 10 ug
EUR 305
Description: Purified recombinant Human TFAM protein
TAF9 protein (His tag)
80R-1656 100 ug
EUR 305
Description: Purified recombinant Human TAF9 protein
SUGT1 protein (His tag)
80R-1657 100 ug
EUR 305
Description: Purified recombinant Human SUGT1 protein
RAB1A protein (His tag)
80R-1658 50 ug
EUR 305
Description: Purified recombinant Human RAB1A protein
PPP3R1 protein (His tag)
80R-1659 100 ug
EUR 305
Description: Purified recombinant Human PPP3R1 protein
EIF1AY protein (His tag)
80R-1660 50 ug
EUR 397
Description: Purified recombinant Human EIF1AY protein
ATG5 protein (His tag)
80R-1661 50 ug
EUR 305
Description: Purified recombinant Human ATG5 protein
FADH1 protein (His tag)
80R-1662 100 ug
EUR 305
Description: Purified recombinant Human FADH1 protein
PEF1 protein (His tag)
80R-1663 50 ug
EUR 305
Description: Purified recombinant Human PEF1 protein
MLF1 protein (His tag)
80R-1664 100 ug
EUR 305
Description: Purified recombinant Human MLF1 protein
RAB21 protein (His tag)
80R-1665 50 ug
EUR 397
Description: Purified recombinant Human RAB21 protein
LCN2 protein (His tag)
80R-1666 100 ug
EUR 397
Description: Purified recombinant Human LCN2 protein
CIB2 protein (His tag)
80R-1667 100 ug
EUR 305
Description: Purified recombinant Human CIB2 protein
NMT2 protein (His tag)
80R-1668 100 ug
EUR 305
Description: Purified recombinant Human NMT2 protein
DNAJC19 protein (His tag)
80R-1669 100 ug
EUR 305
Description: Purified recombinant Human DNAJC19 protein
DHFR protein (His tag)
80R-1670 100 ug
EUR 305
Description: Purified recombinant mouse DHFR protein
IMPA2 protein (His tag)
80R-1671 50 ug
EUR 305
Description: Purified recombinant Human IMPA2 protein
BCAS2 protein (His tag)
80R-1672 10 ug
EUR 305
Description: Purified recombinant Human BCAS2 protein
BLNK protein (His tag)
80R-1673 100 ug
EUR 305
Description: Purified recombinant Human BLNK protein
CCL3L1 protein (His tag)
80R-1674 100 ug
EUR 305
Description: Purified recombinant Human CCL3L1 protein
CCL20 protein (His tag)
80R-1675 50 ug
EUR 397
Description: Purified recombinant Human CCL20 protein
RAB6B protein (His tag)
80R-1676 100 ug
EUR 305
Description: Purified recombinant Human RAB6B protein
SNRPE protein (His tag)
80R-1677 10 ug
EUR 305
Description: Purified recombinant Human SNRPE protein
SF3B14 protein (His tag)
80R-1678 50 ug
EUR 305
Description: Purified recombinant Human SF3B14 protein
RERG protein (His tag)
80R-1679 50 ug
EUR 397
Description: Purified recombinant Human RERG protein
NUDT3 protein (His tag)
80R-1680 50 ug
EUR 305
Description: Purified recombinant Human NUDT3 protein
MYL9 protein (His tag)
80R-1681 50 ug
EUR 305
Description: Purified recombinant Human MYL9 protein
CAPS protein (His tag)
80R-1682 100 ug
EUR 305
Description: Purified recombinant Human CAPS protein
RPS14 protein (His tag)
80R-1683 10 ug
EUR 305
Description: Purified recombinant Human RPS14 protein
LYPLA2 protein (His tag)
80R-1684 100 ug
EUR 397
Description: Purified recombinant Human LYPLA2 protein
ENOPH1 protein (His tag)
80R-1685 100 ug
EUR 397
Description: Purified recombinant Human ENOPH1 protein
ACYP1 protein (His tag)
80R-1686 100 ug
EUR 305
Description: Purified recombinant Human ACYP1 protein
BATF protein (His tag)
80R-1687 100 ug
EUR 305
Description: Purified recombinant Human BATF protein
CCL14 protein (His tag)
80R-1688 100 ug
EUR 305
Description: Purified recombinant Human CCL14 protein
eFIMC protein (His tag)
80R-1689 100 ug
EUR 305
Description: Purified recombinant E.coli eFIMC protein
ERH protein (His tag)
80R-1690 100 ug
EUR 305
Description: Purified recombinant Human ERH protein
MESDC2 protein (His tag)
80R-1691 100 ug
EUR 397
Description: Purified recombinant Human MESDC2 protein
NUDT16L1 protein (His tag)
80R-1692 100 ug
EUR 397
Description: Purified recombinant Human NUDT16L1 protein
NUDT21 protein (His tag)
80R-1693 100 ug
EUR 305
Description: Purified recombinant Human NUDT21 protein
RBP7 protein (His tag)
80R-1694 100 ug
EUR 305
Description: Purified recombinant Human RBP7 protein
SNRPD2 protein (His tag)
80R-1695 100 ug
EUR 397
Description: Purified recombinant Human SNRPD2 protein
TAGLN2 protein (His tag)
80R-1696 100 ug
EUR 305
Description: Purified recombinant Human TAGLN2 protein
TDO2 protein (His tag)
80R-1697 10 ug
EUR 305
Description: Purified recombinant Human TDO2 protein
UFM1 protein (His tag)
80R-1698 100 ug
EUR 305
Description: Purified recombinant Human UFM1 protein

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