Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia.

Astrogliosis and activation of microglia are hallmarks of prion ailments in people and animals. Each have been seen to be reasonably impartial occasions in illness pathophysiology, with proinflammatory microglia thought-about to be the potential neurotoxic species at late illness phases. Latest investigations have offered substantial proof {that a} proinflammatory microglial cytokine cocktail containing TNF-α, IL-1α and C1qa reprograms a subset of astrocytes to alter their expression profile and phenotype, thus changing into neurotoxic (designated as A1-astrocytes). Knockout or antibody blockage of the three cytokines abolish formation of A1-astrocytes, due to this fact, this pathway is of excessive therapeutic curiosity in neurodegenerative ailments.

Since astrocyte polarization profiles have by no means been investigated in prion ailments, we carried out a number of analyses and will present that C3+-PrPSc-reactive-astrocytes, which can symbolize a subtype of A1-astrocytes, are extremely considerable in prion illness mouse fashions and human prion ailments. To analyze their impression on prion illness pathophysiology and to judge their potential therapeutic focusing on, we contaminated TNF-α, IL-1α, and C1qa Triple-KO mice (TKO-mice), which don’t transit astrocytes into A1, with prions. Though formation of C3+-astrocytes was considerably lowered in prion contaminated Triple-KO-mice, this didn’t have an effect on the quantity of PrPSc deposition or titers of infectious prions. Detailed characterization of the astrocyte activation signature in thalamus tissue confirmed that astrocytes in prion ailments are extremely activated, displaying a blended phenotype that’s distinct from different neurodegenerative ailments and have been due to this fact termed C3+-PrPSc-reactive-astrocytes. Unexpectedly, Triple-KO led to a major acceleration of prion illness course.

Whereas pan-astrocyte and -microglia marker upregulation was unchanged in comparison with WT-brains, microglial homeostatic markers have been misplaced early in illness in TKO-mice, pointing in direction of necessary capabilities of various glia cell varieties in prion ailments. The early replication of some orally-acquired prion strains upon stromal-derived follicular dendritic cells (FDC) throughout the small intestinal Peyer’s patches is crucial to determine host an infection, and for the illness to effectively unfold to the mind. Components that affect the early accumulation of prions in Peyer’s patches can immediately affect illness pathogenesis.

The host’s immune response to a gastrointestinal helminth an infection can alter susceptibility to co-infection with sure pathogenic micro organism and viruses. Right here we used the pure mouse small intestine-restricted helminth pathogen Heligmosomoides polygyrus to check the speculation that pathology particularly throughout the small gut attributable to a helminth co-infection would affect oral prion illness pathogenesis.

Okay Google, how may I design therapeutics towards prion ailments?

Plenty of earlier profitable makes an attempt within the seek for therapeutics for a wide range of human pathologies spotlight the significance of computational applied sciences within the drug discovery pipeline. This strategy, also known as computer-aided drug design, is sadly inapplicable when the exact info relating to the three-dimensional construction of disease-associated proteins or the mechanism by which they’re altered to generate misfolded isoforms are lacking.

A typical instance is represented by prion ailments, deadly pathologies of the nervous system characterised by the conformational conversion of a physiological protein referred to as PrPC right into a misfolded and infectious isoform known as PrPSc. Lacking info relating to the atomic construction of PrPSc in addition to the mechanism of templated conversion of PrPC has severely halted the invention of efficient therapies for prion ailments. On this manuscript, we overview rising alternatives to use computer-aided methods to focus on PrPC, PrPSc or to design inhibitors of prion replication, and talk about how these fast-evolving applied sciences may lay the groundwork for the applying of totally novel rational drug design schemes for these devastating pathologies.

Aβ and tau prion-like actions decline with longevity within the Alzheimer’s illness human mind.

The hallmarks of Alzheimer’s illness (AD) are the buildup of Aβ plaques and neurofibrillary tangles composed of hyperphosphorylated tau. We developed delicate mobile assays utilizing human embryonic kidney-293T cells to quantify intracellular self-propagating conformers of Aβ in mind samples from sufferers with AD or different neurodegenerative ailments. Postmortem mind tissue from sufferers with AD had measurable quantities of pathological Aβ conformers. People over 80 years of age had the bottom quantities of prion-like Aβ and phosphorylated tau.

Alpha-bungarotoxin, CF680r
9-00003	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF640r
9-00004	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF640r
9-00004	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a
9-00005	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a
9-00005	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568
9-00006	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568
9-00006	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594
9-00007	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594
9-00007	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633
9-00009	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633
9-00009	Biotium	EUR 494.00 EUR 161.00	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin
00010-1	Biotium	1MG	EUR 168
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin
00011	Biotium	500uG	EUR 367
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin
00012	Biotium	500uG	EUR 383
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)
00013	Biotium	10ST	EUR 417
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)
00014	Biotium	10ST	EUR 466
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)
00015	Biotium	500uG	EUR 466
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)
00016	Biotium	10ST	EUR 523
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin
00017	Biotium	500uG	EUR 433
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate
9-00018	Biotium	EUR 494.00 EUR 161.00	500uG 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate
9-00018	Biotium	EUR 494.00 EUR 161.00	500uG 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:
00020	Biotium	1MG	EUR 314
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)
00020-1	Biotium	20ST	EUR 418
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:
00021	Biotium	1MG	EUR 344
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)
00021-1	Biotium	20ST	EUR 448
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:
00022	Biotium	1MG	EUR 491
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)
00022-1	Biotium	20ST	EUR 625
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:
00023	Biotium	1MG	EUR 281
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine
00025	Biotium	100uG	EUR 139
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543
00026	Biotium	500uG	EUR 494
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u
00027	Biotium	300	EUR 345
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin
00028	Biotium	100U	EUR 428
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin
00030	Biotium	300U	EUR 345
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin
00032	Biotium	300ST	EUR 345
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin
00033	Biotium	300EU	EUR 345
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M
00034	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M
00034-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP
00036	Biotium	100ug	EUR 172
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP
00037	Biotium	100ug	EUR 172
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555
00040	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555
00040-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647
00041	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647
00041-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A
00042	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A
00042-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543
00043	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543
00043-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568
00044	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568
00044-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594
00045	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594
00045-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633
00046	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633
00046-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660R
00047	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660R
00047-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680R
00048	Biotium	300U	EUR 466
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680R
00048-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF350
00049	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF350
00049-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF640R
00050	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF640R
00050-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF532
00051	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF532
00051-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660C
00052	Biotium	300U	EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660C
00052-T	Biotium	50U	EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680
00053	Biotium	300U	EUR 466
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680
00053-T	Biotium	50U	EUR 147
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF430
00054	Biotium	300U	EUR 449
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF430
00054-T	Biotium	50U	EUR 139
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF440
00055	Biotium	300U	EUR 449
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF440
00055-T	Biotium	50U	EUR 139
Description: Minimum order quantity: 1 unit of 50U

Cholera Toxin Subunit B, CF488A conjugate
00070	Biotium	100ug	EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF568 conjugate
00071	Biotium	100ug	EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF594 conjugate
00072	Biotium	100ug	EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF640R conjugate
00073	Biotium	100ug	EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF532 conjugate
00074	Biotium	100ug	EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF543 conjugate
00075	Biotium	100ug	EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF620R conjugate
00076	Biotium	100ug	EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF633 conjugate
00077	Biotium	100ug	EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF660R conjugate
00078	Biotium	100ug	EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF680R conjugate
00079	Biotium	100ug	EUR 282
Description: Minimum order quantity: 1 unit of 100ug

Human Transferrin, CF488A conjugate
00081	Biotium	1mg	EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF543 conjugate
00082	Biotium	1mg	EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF568 conjugate
00083	Biotium	1mg	EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF594 conjugate
00084	Biotium	1mg	EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF640R conjugate
00085	Biotium	1mg	EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF680R conjugate
00086	Biotium	1mg	EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF750 conjugate
00087	Biotium	1mg	EUR 155
Description: Minimum order quantity: 1 unit of 1mg

HIV-1 tat recombinant antigen
00110-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen
00110-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 GAG P24 Recombinant Antigen
00111-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen
00111-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 nef recombinant antigen
00112-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen
00112-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 env gp41 recombinant antigen
00113-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen
00113-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-2 GP 36 Recombinant Antigen
00114-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HIV-2 GP 36 Recombinant Antigen
00114-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HCV core recombinant antigen
00115-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen
00115-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen, Biotin conjugate
00115-V-B-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, Biotin conjugate
00115-V-B-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, FITC conjugate
00115-V-F-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, FITC conjugate
00115-V-F-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, Rhodamine
00115-V-R-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV core recombinant antigen, Rhodamine
00115-V-R-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b
00116-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV NS4 recombinant antigen NS4a+b
00116-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV NS4 recombinant antigen NS4a+b, Biotin
00116-V-B-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV NS4 recombinant antigen NS4a+b, Biotin
00116-V-B-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV NS4 recombinant antigen NS4a+b, FITC
00116-V-F-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b, FITC
00116-V-F-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b, Rhodamine
00116-V-R-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b, Rhodamine
00116-V-R-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS3 recombinant antigen
00117-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HCV NS3 recombinant antigen
00117-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HBV core recombinant antigen
00120-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa

HBV core recombinant antigen
00120-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa

HBV core recombinant antigen, Delta
00121-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa

HBV core recombinant antigen, Delta
00121-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa

HBV surface recombinant antigen HBsAg
00122-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant

HBV surface recombinant antigen HBsAg
00122-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant

HBV surface recombinant antigen HBsAg antigen
00123-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity

HBV surface recombinant antigen HBsAg antigen
00123-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity

HBV surface recombinant antigen HBsAg antigen
00124-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant

HBV surface recombinant antigen HBsAg antigen
00124-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant

HEV (Birma) ORF2 recombinant antigen
00131-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659.

HEV (Birma) ORF2 recombinant antigen
00131-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659.

HEV (Birma) ORF2 recombinant antigen
00132-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461.

HEV (Birma) ORF2 recombinant antigen
00132-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461.

AA 403-461 HEV Birma ORF2 Recombinant Antigen
00133-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123.

AA 403-461 HEV Birma ORF2 Recombinant Antigen
00133-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123.

T, Pallidum recombinant antigen p15
00141-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: T. Pallidum recombinant antigen p15 (full length)

T, Pallidum recombinant antigen p15
00141-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: T. Pallidum recombinant antigen p15 (full length)

T, Pallidum recombinant antigen p17
00142-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: T. Pallidum recombinant antigen p17 (full length)

T, Pallidum recombinant antigen p17
00142-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: T. Pallidum recombinant antigen p17 (full length)

T, Pallidum recombinant antigen p45
00143-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: T. Pallidum recombinant antigen p45 (full length)

T, Pallidum recombinant antigen p45
00143-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: T. Pallidum recombinant antigen p45 (full length)

T, pallidum recombinant antigen TmpA
00144-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: T. Pallidum recombinant antigen TmpA (full length)

T, pallidum recombinant antigen TmpA
00144-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: T. Pallidum recombinant antigen TmpA (full length)

HCV core 2-119aa recombinant antigen
00150-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a

HCV core 2-119aa recombinant antigen
00150-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a

HCV Core 24 Antigen
00151-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV core 24 antigen.

HCV Core 24 Antigen
00151-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV core 24 antigen.

HCV core recombinant antigen
00152-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV core recombinant antigen a.a.105-302

HCV core recombinant antigen
00152-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV core recombinant antigen a.a.105-302

HCV NS3 1192-1456 aa Recombinant Antigen
00153-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS3 1192-1456aa recombinant antigen a.a.1192-1459. Available genotypes: 1a, 1b, 2b, 2c, 5, 6a

HCV NS3 1192-1456 aa Recombinant Antigen
00153-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS3 1192-1456aa recombinant antigen a.a.1192-1459. Available genotypes: 1a, 1b, 2b, 2c, 5, 6a

HCV NS3 1359-1456aa antigen
00154-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS3 1359-1456aa antigen. The protein contains immunodominant regions (1359-1456aa). available genotypes: 1a, 1b, 2b, 3, 4, 5, 6

HCV NS3 1359-1456aa antigen
00154-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS3 1359-1456aa antigen. The protein contains immunodominant regions (1359-1456aa). available genotypes: 1a, 1b, 2b, 3, 4, 5, 6

HCV NS4 mosaic recombinant antigen
00155-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS4 mosaic recombinant antigen a.a1691-1710, 1712-1733, 1921-1940. Genotypes available: 1, 2, 3, 5.

HCV NS4 mosaic recombinant antigen
00155-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS4 mosaic recombinant antigen a.a1691-1710, 1712-1733, 1921-1940. Genotypes available: 1, 2, 3, 5.

HCV NS4 1916-1947aa recombinant antigen
00156-V-01mg	Virogen	0,1 mg	EUR 267.5
Description: HCV NS4 1916-1947aa recombinant antigen.

HCV NS4 1916-1947aa recombinant antigen
00156-V-1000ug	Virogen	1000 ug	EUR 1282.5
Description: HCV NS4 1916-1947aa recombinant antigen.

Unexpectedly, the longevity-dependent lower in self-propagating tau conformers occurred regardless of growing quantities of complete insoluble tau. When corrected for the abundance of insoluble tau, the power of postmortem AD mind homogenates to induce misfolded tau within the mobile assays confirmed an exponential lower with longevity, with a half-life of about one decade over the age vary of 37 to 99 years. Thus, our findings display an inverse correlation between longevity in sufferers with AD and the abundance of pathological tau conformers. Our mobile assays may be utilized to affected person choice for scientific research and the event of latest medicine and diagnostics for AD.