Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia.

Astrogliosis and activation of microglia are hallmarks of prion ailments in people and animals. Each have been seen to be reasonably impartial occasions in illness pathophysiology, with proinflammatory microglia thought-about to be the potential neurotoxic species at late illness phases. Latest investigations have offered substantial proof {that a} proinflammatory microglial cytokine cocktail containing TNF-α, IL-1α and C1qa reprograms a subset of astrocytes to alter their expression profile and phenotype, thus changing into neurotoxic (designated as A1-astrocytes). Knockout or antibody blockage of the three cytokines abolish formation of A1-astrocytes, due to this fact, this pathway is of excessive therapeutic curiosity in neurodegenerative ailments.
Since astrocyte polarization profiles have by no means been investigated in prion ailments, we carried out a number of analyses and will present that C3+-PrPSc-reactive-astrocytes, which can symbolize a subtype of A1-astrocytes, are extremely considerable in prion illness mouse fashions and human prion ailments. To analyze their impression on prion illness pathophysiology and to judge their potential therapeutic focusing on, we contaminated TNF-α, IL-1α, and C1qa Triple-KO mice (TKO-mice), which don’t transit astrocytes into A1, with prions. Though formation of C3+-astrocytes was considerably lowered in prion contaminated Triple-KO-mice, this didn’t have an effect on the quantity of PrPSc deposition or titers of infectious prions. Detailed characterization of the astrocyte activation signature in thalamus tissue confirmed that astrocytes in prion ailments are extremely activated, displaying a blended phenotype that’s distinct from different neurodegenerative ailments and have been due to this fact termed C3+-PrPSc-reactive-astrocytes. Unexpectedly, Triple-KO led to a major acceleration of prion illness course.
Whereas pan-astrocyte and -microglia marker upregulation was unchanged in comparison with WT-brains, microglial homeostatic markers have been misplaced early in illness in TKO-mice, pointing in direction of necessary capabilities of various glia cell varieties in prion ailments. The early replication of some orally-acquired prion strains upon stromal-derived follicular dendritic cells (FDC) throughout the small intestinal Peyer’s patches is crucial to determine host an infection, and for the illness to effectively unfold to the mind. Components that affect the early accumulation of prions in Peyer’s patches can immediately affect illness pathogenesis.
The host’s immune response to a gastrointestinal helminth an infection can alter susceptibility to co-infection with sure pathogenic micro organism and viruses. Right here we used the pure mouse small intestine-restricted helminth pathogen Heligmosomoides polygyrus to check the speculation that pathology particularly throughout the small gut attributable to a helminth co-infection would affect oral prion illness pathogenesis.
Okay Google, how may I design therapeutics towards prion ailments?
Plenty of earlier profitable makes an attempt within the seek for therapeutics for a wide range of human pathologies spotlight the significance of computational applied sciences within the drug discovery pipeline. This strategy, also known as computer-aided drug design, is sadly inapplicable when the exact info relating to the three-dimensional construction of disease-associated proteins or the mechanism by which they’re altered to generate misfolded isoforms are lacking.
A typical instance is represented by prion ailments, deadly pathologies of the nervous system characterised by the conformational conversion of a physiological protein referred to as PrPC right into a misfolded and infectious isoform known as PrPSc. Lacking info relating to the atomic construction of PrPSc in addition to the mechanism of templated conversion of PrPC has severely halted the invention of efficient therapies for prion ailments. On this manuscript, we overview rising alternatives to use computer-aided methods to focus on PrPC, PrPSc or to design inhibitors of prion replication, and talk about how these fast-evolving applied sciences may lay the groundwork for the applying of totally novel rational drug design schemes for these devastating pathologies.

Aβ and tau prion-like actions decline with longevity within the Alzheimer’s illness human mind.
The hallmarks of Alzheimer’s illness (AD) are the buildup of Aβ plaques and neurofibrillary tangles composed of hyperphosphorylated tau. We developed delicate mobile assays utilizing human embryonic kidney-293T cells to quantify intracellular self-propagating conformers of Aβ in mind samples from sufferers with AD or different neurodegenerative ailments. Postmortem mind tissue from sufferers with AD had measurable quantities of pathological Aβ conformers. People over 80 years of age had the bottom quantities of prion-like Aβ and phosphorylated tau.
Alpha-bungarotoxin, CF680r |
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9-00003 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
Alpha-bungarotoxin, CF640r |
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9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
Alpha-bungarotoxin, CF640r |
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9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
Alpha-bungarotoxin, CF488a |
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9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
Alpha-bungarotoxin CF488a |
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9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
Alpha-bungarotoxin, CF568 |
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9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
Alpha-bungarotoxin, CF568 |
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9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
Alpha-bungarotoxin, CF594 |
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9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
Alpha-bungarotoxin CF594 |
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9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
Alpha-bungarotoxin, CF633 |
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9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
Alpha-bungarotoxin, CF633 |
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9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
Alpha-bungarotoxin |
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00010-1 | Biotium | 1MG | EUR 201.6 |
Description: Minimum order quantity: 1 unit of 1MG |
Fluorescein-Alpha-bungarotoxin |
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00011 | Biotium | 500uG | EUR 440.4 |
Description: Minimum order quantity: 1 unit of 500uG |
Tetramethylrhodamine-Alpha-bungarotoxin |
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00012 | Biotium | 500uG | EUR 459.6 |
Description: Minimum order quantity: 1 unit of 500uG |
Fluorescein-alpha-bungarotoxin: (10x50ug) |
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00013 | Biotium | 10ST | EUR 500.4 |
Description: Minimum order quantity: 1 unit of 10ST |
Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug) |
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00014 | Biotium | 10ST | EUR 559.2 |
Description: Minimum order quantity: 1 unit of 10ST |
Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug) |
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00015 | Biotium | 500uG | EUR 559.2 |
Description: Minimum order quantity: 1 unit of 500uG |
Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug) |
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00016 | Biotium | 10ST | EUR 627.6 |
Description: Minimum order quantity: 1 unit of 10ST |
Biotin-xx-a-bungarotoxin |
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00017 | Biotium | 500uG | EUR 519.6 |
Description: Minimum order quantity: 1 unit of 500uG |
Alpha-Bungarotoxin, CF555 conjugate |
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9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
Alpha-Bungarotoxin, CF555 conjugate |
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9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 100ug |
Biotin-cAMP, diisopropylethylammonium salt: |
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00020 | Biotium | 1MG | EUR 376.8 |
Description: Minimum order quantity: 1 unit of 1MG |
Biotin-cAMP, diisopropylethylammonium salt: (20x50ug) |
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00020-1 | Biotium | 20ST | EUR 501.6 |
Description: Minimum order quantity: 1 unit of 20ST |
Biotin-cGMP, diisopropylethylammonium salt: |
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00021 | Biotium | 1MG | EUR 412.8 |
Description: Minimum order quantity: 1 unit of 1MG |
Biotin-cGMP, diisopropylethylammonium salt: (20x50ug) |
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00021-1 | Biotium | 20ST | EUR 537.6 |
Description: Minimum order quantity: 1 unit of 20ST |
Cyanine 644-cAMP: |
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00022 | Biotium | 1MG | EUR 589.2 |
Description: Minimum order quantity: 1 unit of 1MG |
Cyanine 644-cAMP: (20x50ug) |
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00022-1 | Biotium | 20ST | EUR 750 |
Description: Minimum order quantity: 1 unit of 20ST |
Fluorescein Methotrexate, triammonium salt: |
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00023 | Biotium | 1MG | EUR 337.2 |
Description: Minimum order quantity: 1 unit of 1MG |
Staurosporine |
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00025 | Biotium | 100uG | EUR 166.8 |
Description: Minimum order quantity: 1 unit of 100uG |
Alpha-bungarotoxin, CF543 |
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00026 | Biotium | 500uG | EUR 592.8 |
Description: Minimum order quantity: 1 unit of 500uG |
Rhodamine phalloidin 300u |
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00027 | Biotium | 300 | EUR 414 |
Description: Minimum order quantity: 1 unit of 300 |
Biotin-xx-phalloidin |
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00028 | Biotium | 100U | EUR 513.6 |
Description: Minimum order quantity: 1 unit of 100U |
Fluorescein-phalloidin |
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00030 | Biotium | 300U | EUR 414 |
Description: Minimum order quantity: 1 unit of 300U |
Rhodamine 110 phalloidin |
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00032 | Biotium | 300ST | EUR 414 |
Description: Minimum order quantity: 1 unit of 300ST |
Sulforhodamine 101 (Texas-Red) Phalloidin |
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00033 | Biotium | 300EU | EUR 414 |
Description: Minimum order quantity: 1 unit of 300EU |
Phalloidin, CF405M |
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00034 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF405M |
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00034-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
CF488A-cAMP |
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00036 | Biotium | 100ug | EUR 206.4 |
Description: Minimum order quantity: 1 unit of 100ug |
CF640R-cAMP |
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00037 | Biotium | 100ug | EUR 206.4 |
Description: Minimum order quantity: 1 unit of 100ug |
Phalloidin, CF555 |
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00040 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF555 |
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00040-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF647 |
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00041 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF647 |
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00041-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF488A |
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00042 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF488A |
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00042-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF543 |
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00043 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF543 |
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00043-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF568 |
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00044 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF568 |
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00044-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF594 |
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00045 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF594 |
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00045-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF633 |
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00046 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF633 |
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00046-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF660R |
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00047 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF660R |
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00047-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF680R |
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00048 | Biotium | 300U | EUR 559.2 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF680R |
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00048-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF350 |
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00049 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF350 |
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00049-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF640R |
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00050 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF640R |
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00050-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF532 |
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00051 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF532 |
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00051-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF660C |
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00052 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF660C |
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00052-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF680 |
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00053 | Biotium | 300U | EUR 559.2 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF680 |
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00053-T | Biotium | 50U | EUR 176.4 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF430 |
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00054 | Biotium | 300U | EUR 538.8 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF430 |
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00054-T | Biotium | 50U | EUR 166.8 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF440 |
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00055 | Biotium | 300U | EUR 538.8 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF440 |
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00055-T | Biotium | 50U | EUR 166.8 |
Description: Minimum order quantity: 1 unit of 50U |
Cholera Toxin Subunit B, CF488A conjugate |
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00070 | Biotium | 100ug | EUR 313.2 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF568 conjugate |
|||
00071 | Biotium | 100ug | EUR 313.2 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF594 conjugate |
|||
00072 | Biotium | 100ug | EUR 313.2 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF640R conjugate |
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00073 | Biotium | 100ug | EUR 316.8 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF532 conjugate |
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00074 | Biotium | 100ug | EUR 316.8 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF543 conjugate |
|||
00075 | Biotium | 100ug | EUR 316.8 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF620R conjugate |
|||
00076 | Biotium | 100ug | EUR 316.8 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF633 conjugate |
|||
00077 | Biotium | 100ug | EUR 316.8 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF660R conjugate |
|||
00078 | Biotium | 100ug | EUR 316.8 |
Description: Minimum order quantity: 1 unit of 100ug |
Cholera Toxin Subunit B, CF680R conjugate |
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00079 | Biotium | 100ug | EUR 338.4 |
Description: Minimum order quantity: 1 unit of 100ug |
Human Transferrin, CF488A conjugate |
|||
00081 | Biotium | 1mg | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 1mg |
Human Transferrin, CF543 conjugate |
|||
00082 | Biotium | 1mg | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 1mg |
Human Transferrin, CF568 conjugate |
|||
00083 | Biotium | 1mg | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 1mg |
Human Transferrin, CF594 conjugate |
|||
00084 | Biotium | 1mg | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 1mg |
Human Transferrin, CF640R conjugate |
|||
00085 | Biotium | 1mg | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 1mg |
Human Transferrin, CF680R conjugate |
|||
00086 | Biotium | 1mg | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 1mg |
Human Transferrin, CF750 conjugate |
|||
00087 | Biotium | 1mg | EUR 186 |
Description: Minimum order quantity: 1 unit of 1mg |
HIV-1 tat recombinant antigen |
|||
00110-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV-1 tat recombinant antigen full length 15 kDa |
HIV-1 tat recombinant antigen |
|||
00110-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV-1 tat recombinant antigen full length 15 kDa |
HIV-1 GAG P24 Recombinant Antigen |
|||
00111-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
HIV-1 GAG P24 Recombinant Antigen |
|||
00111-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
HIV-1 nef recombinant antigen |
|||
00112-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
HIV-1 nef recombinant antigen |
|||
00112-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
HIV-1 env gp41 recombinant antigen |
|||
00113-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
HIV-1 env gp41 recombinant antigen |
|||
00113-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
HIV-2 GP 36 Recombinant Antigen |
|||
00114-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
HIV-2 GP 36 Recombinant Antigen |
|||
00114-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
HCV core recombinant antigen |
|||
00115-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
HCV core recombinant antigen |
|||
00115-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
HCV core recombinant antigen, Biotin conjugate |
|||
00115-V-B-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
HCV core recombinant antigen, Biotin conjugate |
|||
00115-V-B-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
HCV core recombinant antigen, FITC conjugate |
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00115-V-F-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
HCV core recombinant antigen, FITC conjugate |
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00115-V-F-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
HCV core recombinant antigen, Rhodamine |
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00115-V-R-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
HCV core recombinant antigen, Rhodamine |
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00115-V-R-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
HCV NS4 recombinant antigen NS4a+b |
|||
00116-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
HCV NS4 recombinant antigen NS4a+b |
|||
00116-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
HCV NS4 recombinant antigen NS4a+b, Biotin |
|||
00116-V-B-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
HCV NS4 recombinant antigen NS4a+b, Biotin |
|||
00116-V-B-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
HCV NS4 recombinant antigen NS4a+b, FITC |
|||
00116-V-F-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
HCV NS4 recombinant antigen NS4a+b, FITC |
|||
00116-V-F-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
HCV NS4 recombinant antigen NS4a+b, Rhodamine |
|||
00116-V-R-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
HCV NS4 recombinant antigen NS4a+b, Rhodamine |
|||
00116-V-R-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
HCV NS3 recombinant antigen |
|||
00117-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
HCV NS3 recombinant antigen |
|||
00117-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
HBV core recombinant antigen |
|||
00120-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
HBV core recombinant antigen |
|||
00120-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
HBV core recombinant antigen, Delta |
|||
00121-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
HBV core recombinant antigen, Delta |
|||
00121-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
HBV surface recombinant antigen HBsAg |
|||
00122-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
HBV surface recombinant antigen HBsAg |
|||
00122-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
HBV surface recombinant antigen HBsAg antigen |
|||
00123-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
HBV surface recombinant antigen HBsAg antigen |
|||
00123-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
HBV surface recombinant antigen HBsAg antigen |
|||
00124-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
HBV surface recombinant antigen HBsAg antigen |
|||
00124-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
HEV (Birma) ORF2 recombinant antigen |
|||
00131-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
HEV (Birma) ORF2 recombinant antigen |
|||
00131-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
HEV (Birma) ORF2 recombinant antigen |
|||
00132-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
HEV (Birma) ORF2 recombinant antigen |
|||
00132-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
AA 403-461 HEV Birma ORF2 Recombinant Antigen |
|||
00133-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
AA 403-461 HEV Birma ORF2 Recombinant Antigen |
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00133-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
T, Pallidum recombinant antigen p15 |
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00141-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: T. Pallidum recombinant antigen p15 (full length) |
T, Pallidum recombinant antigen p15 |
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00141-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: T. Pallidum recombinant antigen p15 (full length) |
T, Pallidum recombinant antigen p17 |
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00142-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: T. Pallidum recombinant antigen p17 (full length) |
T, Pallidum recombinant antigen p17 |
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00142-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: T. Pallidum recombinant antigen p17 (full length) |
T, Pallidum recombinant antigen p45 |
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00143-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: T. Pallidum recombinant antigen p45 (full length) |
T, Pallidum recombinant antigen p45 |
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00143-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: T. Pallidum recombinant antigen p45 (full length) |
T, pallidum recombinant antigen TmpA |
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00144-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: T. Pallidum recombinant antigen TmpA (full length) |
T, pallidum recombinant antigen TmpA |
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00144-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: T. Pallidum recombinant antigen TmpA (full length) |
HCV core 2-119aa recombinant antigen |
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00150-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
HCV core 2-119aa recombinant antigen |
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00150-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
HCV Core 24 Antigen |
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00151-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV core 24 antigen. |
HCV Core 24 Antigen |
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00151-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV core 24 antigen. |
HCV core recombinant antigen |
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00152-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV core recombinant antigen a.a.105-302 |
HCV core recombinant antigen |
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00152-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV core recombinant antigen a.a.105-302 |
HCV NS3 1192-1456 aa Recombinant Antigen |
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00153-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS3 1192-1456aa recombinant antigen a.a.1192-1459. Available genotypes: 1a, 1b, 2b, 2c, 5, 6a |
HCV NS3 1192-1456 aa Recombinant Antigen |
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00153-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS3 1192-1456aa recombinant antigen a.a.1192-1459. Available genotypes: 1a, 1b, 2b, 2c, 5, 6a |
HCV NS3 1359-1456aa antigen |
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00154-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS3 1359-1456aa antigen. The protein contains immunodominant regions (1359-1456aa). available genotypes: 1a, 1b, 2b, 3, 4, 5, 6 |
HCV NS3 1359-1456aa antigen |
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00154-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS3 1359-1456aa antigen. The protein contains immunodominant regions (1359-1456aa). available genotypes: 1a, 1b, 2b, 3, 4, 5, 6 |
HCV NS4 mosaic recombinant antigen |
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00155-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS4 mosaic recombinant antigen a.a1691-1710, 1712-1733, 1921-1940. Genotypes available: 1, 2, 3, 5. |
HCV NS4 mosaic recombinant antigen |
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00155-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS4 mosaic recombinant antigen a.a1691-1710, 1712-1733, 1921-1940. Genotypes available: 1, 2, 3, 5. |
HCV NS4 1916-1947aa recombinant antigen |
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00156-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HCV NS4 1916-1947aa recombinant antigen. |
HCV NS4 1916-1947aa recombinant antigen |
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00156-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HCV NS4 1916-1947aa recombinant antigen. |
Unexpectedly, the longevity-dependent lower in self-propagating tau conformers occurred regardless of growing quantities of complete insoluble tau. When corrected for the abundance of insoluble tau, the power of postmortem AD mind homogenates to induce misfolded tau within the mobile assays confirmed an exponential lower with longevity, with a half-life of about one decade over the age vary of 37 to 99 years. Thus, our findings display an inverse correlation between longevity in sufferers with AD and the abundance of pathological tau conformers. Our mobile assays may be utilized to affected person choice for scientific research and the event of latest medicine and diagnostics for AD.