In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases.

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In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases.

Prion-like habits has been within the highlight because it was first related to the onset of mammalian neurodegenerative illnesses. Nevertheless, a rising physique of proof means that this mechanism may very well be behind the regulation of processes similar to transcription and translation in a number of species. Right here, we carry out a stringent computational survey to establish prion-like proteins within the human proteome. We detected 242 candidate polypeptides and computationally assessed their operate, protein-protein interplay networks, tissular expression, and their hyperlink to illness. Human prion-like proteins represent a subset of modular polypeptides broadly expressed throughout totally different cell varieties and tissues, considerably related to illness, embedded in extremely related interplay networks, and concerned within the stream of genetic data within the cell.

Our evaluation means that these proteins may play a related function not solely in neurological issues, but additionally in several types of most cancers and viral infections. Prion illnesses are quickly progressive neurodegenerative situations that may be tough to diagnose and are transmissible underneath particular circumstances. The authors will present background concerning prion illness and give attention to diagnostic instruments.Prion illness is brought on by misfolded prion protein. The three doable causes of prion illness embody sporadic (85%), genetic (10-15%), and purchased (<1%). Acquired prion illnesses embody kuru, iatrogenic, and variant Creutzfeldt-Jakob illness. Prion illnesses differ of their scientific manifestation, neuropathology, and diagnostic take a look at outcomes.

Quite a lot of latest diagnostic instruments have developed that enable extra dependable antemortem prognosis of prion illness similar to mind MRI and cerebrospinal fluid real-time quaking-induced conversion. Particular infectivity tips should be adopted when coping with central nervous system tissue, however solely normal precautions are wanted for routine scientific care of sufferers with prion illness.The one method to undoubtedly diagnose prion illness and decide its kind is by way of neuropathologic examination. Nevertheless, mind MRI and cerebrospinal fluid real-time quaking-induced conversion have drastically elevated diagnostic accuracy and are essential exams to make use of when evaluating sufferers with suspected prion illness.

Axonal modifications in experimental prion illnesses recapitulate these following constriction of postganglionic branches of the superior cervical ganglion: a comparability 40 years later.

The key neurological function of prion illnesses is a neuronal loss completed via both apoptosis or autophagy. On this evaluate, I in contrast axonal alterations in prion illnesses to these described 40 years earlier because of nerve ligation. I additionally demonstrated that autophagic vacuoles and autophagosomes are a significant a part of dystrophic neurites.

Moreover, I summarized the present standing of the autophagy in prion illnesses and hypothesize, that spongiform change might originate from the autophagic vacuoles. This conclusion must be supported by different strategies, specifically laser confocal microscopy. We noticed neuronal autophagic vacuoles in several phases of formation, and our interpretation of the ‘maturity’ of their formation might or might not equate to precise developmental phases. Initially, part of the neuronal cytoplasm was sequestrated inside double or a number of membranes (phagophores) and sometimes exhibited elevated electron-density.

The intracytoplasmic membranes shaped labyrinth-like buildings that counsel a multiplication of these membranes. The autophagic vacuoles then develop and ultimately, an enormous space of the cytoplasm was reworked right into a merging mass of autophagic vacuoles. Margaret R. Matthews revealed an extended treatise within the Philosophical Transactions of the Royal Society of London through which she had described in nice element the ultrastructure of postganglionic branches of the superior cervical ganglion within the rat following ligation of them. The earliest modifications noticed by Matthews between 6 h to 2 days within the proximal stump have been distensions of proximal axons. Analogously, in our fashions, an elevated variety of ‘common’ (spherical) and ‘irregular’ MVB and a few autophagic vacuoles have been noticed collectively, each processes have been comparable.

 In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases.
In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases.

Prion protein quantification in human cerebrospinal fluid as a software for prion illness drug growth.

Discount of native prion protein (PrP) ranges within the mind is a beautiful technique for the remedy or prevention of human prion illness. Medical growth of any PrP-reducing therapeutic would require an acceptable pharmacodynamic biomarker: a sensible and sturdy methodology for quantifying PrP, and reliably demonstrating its discount within the central nervous system (CNS) of a residing affected person. Right here we consider the potential of ELISA-based quantification of human PrP in human cerebrospinal fluid (CSF) to function a biomarker for PrP-reducing therapeutics.

We present that CSF PrP is very delicate to plastic adsorption throughout dealing with and storage, however its loss may be minimized by the addition of detergent. We discover that blood contamination doesn’t have an effect on CSF PrP ranges, and that CSF PrP and hemoglobin are uncorrelated, collectively suggesting that CSF PrP is CNS derived, supporting its relevance for monitoring the tissue of curiosity and in step with excessive PrP abundance in mind relative to blood. In a cohort with managed pattern dealing with, CSF PrP displays good within-subject test-retest reliability (imply coefficient of variation, 13% in samples collected 8-11 wk aside), a sufficiently secure baseline to permit therapeutically significant reductions in mind PrP to be readily detected in CSF.

Major Prion Protein (CD230) Antibody

abx415316-01mg 0.1 mg
EUR 543.6

Major Prion Protein (CD230) Antibody

20-abx141693
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Major Prion Protein (CD230) Antibody

abx139819-01mg 0.1 mg
EUR 610.8

Prion Protein/CD230

CH23027 200 ul
EUR 553.2

Prion Protein(PrP) Antibody

48939 100ul
EUR 499

Prion Protein(PrP) Antibody

48939-100ul 100ul
EUR 399.6

Prion Protein(PrP) Antibody

48939-50ul 50ul
EUR 286.8

Prion Protein (PrP) Antibody

abx120080-01ml 0.1 ml
EUR 944.4

PrP Antibody / Prion protein

RQ5040 100ul
EUR 356.15
Description: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. [RefSeq]

PrP Antibody Prion protein

R30892 100 ug
EUR 356.15
Description: Prion protein, also known as CD230 and PrP, is a protein that in humans is encoded by the PRNP gene. Expression is predominantly in the nervous system but occurs to some degree in many other tissues throughout the body. Puckett et al.(1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PrP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. The protein is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid sequences.

Prion protein Antibody (PrP)

R30893 100 ug
EUR 356.15
Description: Prion protein, also known as CD230 and PRP, is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al.(1991) identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru.

Prion protein Antibody (PrP)

R31881 100 ug
EUR 356.15
Description: PRNP (prion protein), also known as CD230 or PrP, is a protein that in humans is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al. (1991) identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. PRNP is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid sequences.

Prion Protein(PrP) Conjugated Antibody

C48939 100ul
EUR 476.4

Prion Protein (PrP)

E8ET1610-27 100ul
EUR 275
Description: Available in various conjugation types.

Cluster of Differentiation 230 Prion Protein Disease Form (CD230 PrPSc) Antibody

abx414218-025mg 0.25 mg
EUR 710.4

Prion protein PrP (PRNP) chicken polyclonal antibody

CH23027-200 200 µl Ask for price

Prion protein PrP (PRNP) goat polyclonal antibody, Serum

AP05815PU-N 100 µl Ask for price

Anti-Hu CD230 / Prion Purified

11-593-C025 0.025 mg
EUR 77

Anti-Hu CD230 / Prion Purified

11-593-C100 0.1 mg
EUR 154

Anti-Hu CD230 / Prion Purified

11-604-C100 0.1mg
EUR 154

Prion Protein (106-126) / PrP (106-126) (Human, Monkey)

034-17 100 μg
EUR 250.56

Prion protein PrP (PRNP) (93-109) mouse monoclonal antibody, clone 6D11, Purified

AM05042PU-N 0.1 ml Ask for price

Prion protein PrP (PRNP) mouse monoclonal antibody, clone EM-20, Aff - Purified

AM26026PU-N 100 µg Ask for price

Prion Protein (PrPsc), Antibody

GWB-8BFFBE 0.1 mg Purified Ask for price

Prion Protein Antibody

GWB-A4A383 0.2 mg Ask for price

Prion Protein Antibody

GWB-93B6D6 0.1 ml Ask for price

Recombinant Human PRP/CD230/PRNP Protein, No Tag

E40KMH1610 20ug
EUR 495

Prion Protein (PRNP) Antibody

abx431521-200ul 200 ul
EUR 460.8

Prion Protein (PRNP) Antibody

20-abx101113
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Prion Protein (PRNP) Antibody

20-abx101114
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Prion Protein (PRNP) Antibody

20-abx174157
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Prion Protein (PRNP) Antibody

abx120079-01ml 0.1 ml
EUR 1779.6

Prion Protein (PRNP) Antibody

20-abx114678
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Prion Protein (PRNP) Antibody

abx002019-100l 100 µl
EUR 387.5

Prion Protein (PRNP) Antibody

abx002019-20l 20 µl
EUR 175

Prion Protein (PRNP) Antibody

abx002019-50l 50 µl
EUR 275

Prion Protein (PRNP) Antibody

abx227053-100g 100 µg
EUR 325

Prion Protein (PRNP) Antibody

abx114678-100l 100 µl
EUR 612.5

Prion Protein (PRNP) Antibody

abx139819-100g 100 µg
EUR 425

Prion Protein (PRNP) Antibody

abx101113-100l 100 µl
EUR 262.5

Prion Protein (PRNP) Antibody

abx101113-1ml 1 ml
EUR 712.5

Prion Protein (PRNP) Antibody

abx101113-200l 200 µl
EUR 325

Prion Protein (PRNP) Antibody

abx101114-100l 100 µl
EUR 262.5

Prion Protein (PRNP) Antibody

abx101114-1ml 1 ml
EUR 725

Prion Protein (PRNP) Antibody

abx101114-200l 200 µl
EUR 337.5

Prion Protein (PRNP) Antibody

abx174157-100l 100 µl
EUR 750

Prion Protein (PRNP) Antibody

abx174157-1ml 1 ml Ask for price

Prion Protein (PRNP) Antibody

abx174157-200l 200 µl Ask for price

Prion Protein (PRNP) Antibody

abx319681-100l 100 µl
EUR 250

Prion Protein (PRNP) Antibody

abx319681-50l 50 µl
EUR 162.5

Prion Protein (PRNP) Antibody

abx431521-200l 200 µl
EUR 387.5

Prion Protein (PRNP) Antibody

abx333875-100g 100 µg
EUR 362.5

Prion Protein (PRNP) Antibody

abx333875-20g 20 µg
EUR 162.5

Prion Protein (PRNP) Antibody

abx333875-50g 50 µg
EUR 250

Prion Protein (PRNP) Antibody

abx414218-200l 200 µl
EUR 512.5

Prion Protein (PRNP) Antibody

abx415314-200l 200 µl
EUR 362.5

Prion Protein (PRNP) Antibody

abx415315-200l 200 µl
EUR 362.5

Prion Protein (PRNP) Antibody

abx415316-200l 200 µl
EUR 362.5

Polyclonal Prion Protein Antibody

APR12947G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Chicken that recognizes and binds to Human Prion Protein . This antibody is tested and proven to work in the following applications:

Prion Protein Polyclonal Antibody

E-AB-92393-120uL 120uL
EUR 320
Description: Unconjugated

Prion Protein Polyclonal Antibody

E-AB-92393-200uL 200uL
EUR 530
Description: Unconjugated

Prion Protein Polyclonal Antibody

E-AB-92393-60uL 60uL
EUR 200
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Prion Protein Polyclonal Antibody

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Prion Protein 2 (PRND) Antibody

20-abx114679
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Prion Protein 2 (PRND) Antibody

abx114679-100l 100 µl
EUR 612.5

Prion Protein (PRNP) Antibody (HRP)

abx319682-100l 100 µl
EUR 250

Prion Protein (PRNP) Antibody (HRP)

abx319682-50l 50 µl
EUR 162.5

Prion Protein (PRNP) Antibody (HRP)

abx336435-100g 100 µg
EUR 362.5

Prion Protein (PRNP) Antibody (HRP)

abx336435-20g 20 µg
EUR 162.5

Prion Protein (PRNP) Antibody (HRP)

abx336435-50g 50 µg
EUR 250

Prion Protein (PRNP) Antibody Pair

20-abx370619
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Prion Protein (PRNP) Antibody Pair

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Prion Protein (PRNP) Antibody Pair

20-abx370621
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Prion Protein (PRNP) Antibody (FITC)

abx319683-100l 100 µl
EUR 250

Prion Protein (PRNP) Antibody (FITC)

abx319683-50l 50 µl
EUR 162.5

Prion Protein (PRNP) Antibody Pair

abx370619-100g 100 µg
EUR 2550

Prion Protein (PRNP) Antibody Pair

abx370619-50g 50 µg
EUR 1575

Prion Protein (PRNP) Antibody Pair

abx370620-100g 100 µg
EUR 2312.5

Prion Protein (PRNP) Antibody Pair

abx370620-50g 50 µg
EUR 1437.5

Prion Protein (PRNP) Antibody Pair

abx370621-100g 100 µg
EUR 2250

Prion Protein (PRNP) Antibody Pair

abx370621-50g 50 µg
EUR 1400

Prion Protein (PRNP) Antibody (FITC)

abx336436-100g 100 µg
EUR 362.5

Prion Protein (PRNP) Antibody (FITC)

abx336436-20g 20 µg
EUR 162.5

Prion Protein (PRNP) Antibody (FITC)

abx336436-50g 50 µg
EUR 250

Major Prion Protein (PRNP) Antibody

20-abx319681
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Major Prion Protein (PRNP) Antibody

20-abx333875
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Major Prion Protein (PRNP) Antibody

20-abx002019
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Major Prion Protein (PRNP) Antibody

abx140599-100g 100 µg
EUR 425

Prion Protein (PRNP) Antibody (Biotin)

abx319684-100l 100 µl
EUR 250

Prion Protein (PRNP) Antibody (Biotin)

abx319684-50l 50 µl
EUR 162.5

Prion Protein (PRNP) Antibody (Biotin)

abx336437-100g 100 µg
EUR 362.5

Prion Protein (PRNP) Antibody (Biotin)

abx336437-20g 20 µg
EUR 162.5

Prion Protein (PRNP) Antibody (Biotin)

abx336437-50g 50 µg
EUR 250

Anti-Prion protein PrP/PRNP Antibody

PB9783 100ug/vial
EUR 400.8

Anti-Prion protein PrP/PRNP Antibody

PA1794 100ug/vial
EUR 352.8

Anti-Prion protein PrP/PRNP Antibody

PA1795 100ug/vial
EUR 400.8

Prion Protein (PRNP) Polyclonal Antibody

CAU25509-100ul 100ul
EUR 229.4

Prion Protein (PRNP) Polyclonal Antibody

CAU25509-200ul 200ul
EUR 287.3

Prion Protein (PRNP) Polyclonal Antibody

CAU25510-100ul 100ul
EUR 222.7

Prion Protein (PRNP) Polyclonal Antibody

CAU25510-200ul 200ul
EUR 278.9

Rabbit Polyclonal Prion protein Antibody

TA590315 100 µg Ask for price

Rabbit Polyclonal Prion protein Antibody

TA336429 100 µg Ask for price

Rabbit Polyclonal Prion protein Antibody

TA336430 100 µg Ask for price

Rabbit Polyclonal Prion protein Antibody

TA336431 100 µg Ask for price

Prion Protein Rabbit Monoclonal Antibody

E10G21880 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Prion Protein Rabbit Polyclonal Antibody

E10G22816 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti- Prion protease-resistant protein 27-30 (PrP27-30) N-Terminal Antibody

GWB-8D9823 0.25 ml Ask for price

Anti- Prion protease-resistant protein 27-30 (PrP27-30) N-Terminal Antibody

GWB-92178F 0.1 ml Ask for price

Prion Protein-Interacting Protein (PRNIP) Antibody

abx032619-400ul 400 ul
EUR 627.6

Prion Protein-Interacting Protein (PRNIP) Antibody

abx032619-80l 80 µl
EUR 343.2

Prion Protein-Interacting Protein (PRNIP) Antibody

abx032619-400l 400 µl
EUR 518.75

Major Prion Protein (PRNP) Antibody (HRP)

20-abx336435
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Major Prion Protein (PRNP) Antibody (HRP)

20-abx319682
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Shadow Of Prion Protein (SPRN) Antibody

20-abx339404
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Shadow of Prion Protein (SPRN) Antibody

abx032300-400ul 400 ul
EUR 627.6

Shadow of Prion Protein (SPRN) Antibody

abx032300-80l 80 µl
EUR 343.2

Shadow of Prion Protein (SPRN) Antibody

abx032300-200l 200 µl
EUR 518.75

Shadow of Prion Protein (SPRN) Antibody

abx032300-50l 50 µl
EUR 281.25

Shadow Of Prion Protein (SPRN) Antibody

abx339404-100l 100 µl
EUR 350

Shadow Of Prion Protein (SPRN) Antibody

abx339404-50l 50 µl
EUR 250

Major Prion Protein (PRNP) Antibody (FITC)

20-abx336436
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Major Prion Protein (PRNP) Antibody (FITC)

20-abx319683
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Prion Protein recombinant monoclonal antibody

A5436 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human Prion Protein for WB, IHC,ELISA

Major Prion Protein (PRNP) Antibody (Biotin)

20-abx336437
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Major Prion Protein (PRNP) Antibody (Biotin)

20-abx319684
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Polyclonal Antibody to Prion Protein (PRNP)

PAB680Hu01 100ul
EUR 232

Polyclonal Antibody to Prion Protein (PRNP)

PAB680Hu02 100ul
EUR 240

Polyclonal Antibody to Prion Protein (PRNP)

PAB680Mu01 100ul
EUR 239

Anti-Prion Protein(PrP) Antibody [SC57-05]

ET1610-27 100ul
EUR 231
Description: Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Characteristic of prion diseases, cellular PrP (PrPc) is converted to the disease form, PrPSc, through alterations in the protein folding conformations. PrPc is constitutively expressed in normal adult brain and is sensitive to proteinase K digestion, while the altered PrPSc conformation is resistant to proteases, resulting in a distinct molecular mass after PK treatment. Consistent with the transient infection process of prion diseases, incubation of PrPc with PrPSc both in vitro and in vivo produces PrPc that is resistant to protease degradation. Infectious PrPSc is found at high levels in the brains of animals affected by TSEs, including scrapie in sheep, BSE in cattle and Cruetzfeldt-Jakob disease in humans.

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse)

4-PAB680Hu01
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Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP)

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat)

4-PAB680Mu01
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Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP)

Goat Polyclonal Antibody against Prion Protein (143-153)

TA302683 100 µg Ask for price

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), PE

4-PAB680Hu01-PE
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Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with PE.

Prion Protein (PRNP) Polyclonal Antibody (Mouse, Rat), PE

4-PAB680Mu01-PE
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Description: A Rabbit polyclonal antibody against Mouse, Rat Prion Protein (PRNP). This antibody is labeled with PE.

Prion-Like Protein Doppel (PRND) Antibody

20-abx322158
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Prion-Like Protein Doppel (PRND) Antibody

20-abx320384
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Prion-Like Protein Doppel (Prnd) Antibody

abx236794-100ug 100 ug
EUR 661.2

Prion-Like Protein Doppel (PRND) Antibody

20-abx006423
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Prion-Like Protein Doppel (Prnd) Antibody

abx236794-100g 100 µg
EUR 350

Prion-Like Protein Doppel (PRND) Antibody

abx320384-100l 100 µl
EUR 350

Prion-Like Protein Doppel (PRND) Antibody

abx320384-50l 50 µl
EUR 237.5

Prion-Like Protein Doppel (PRND) Antibody

abx322158-100g 100 µg
EUR 350

Prion-Like Protein Doppel (PRND) Antibody

abx322158-50g 50 µg
EUR 237.5

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), APC

4-PAB680Hu01-APC
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Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with APC.

Prion Protein (PRNP) Polyclonal Antibody (Rat, Mouse), Cy3

4-PAB680Hu01-Cy3
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat, Mouse Prion Protein (PRNP). This antibody is labeled with Cy3.

Collectively, these findings provide a way for monitoring the impact of a PrP-reducing drug within the CNS, and can facilitate growth of prion illness therapeutics with this mechanism of motion.

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