Elisa Assay Disease Detection

Alzheimers Disease gamma-Secretase Detection Set

PSI-1820 1 Set
EUR 752.1
Description: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The β-amyloid protein precursor (APP) is cleaved by three enzymes (TACE, BACE/BACE2 and γ-secretase) at three distinct sites (α, β and γ respectively). The γ-secretase complex is a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer and is composed of the proteins APH1, nicastrin, PEN2 and presenilin1. Its cleavage of APP results in either the non-toxic p3 (from the α and γ cleavage site) or the toxic Aβ (from the β and γ cleavage site). APH1 was initially identified as a component of the Notch pathway and exists in at least three distinct isoforms with APH1a as the principal isoform present in the γ-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. Besides acting as a critical component of the γ-secretase complex, nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of nicastrin expression results in mouse embryonic lethality. Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer’s disease.;;For images please see PDF data sheet

Assay Elisa Laboratories manufactures the elisa assay disease detection reagents distributed by Genprice. The Elisa Assay Disease Detection reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Assay elisa. Other Elisa products are available in stock. Specificity: Elisa Category: Assay Group: Disease Detection

Mouse CXCL13 Detection Assay Kit

1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse CCL17 Detection Assay Kit

1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse CCL20 Detection Assay Kit

1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse CCL22 Detection Assay Kit

1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Human CCL5 Detection Assay Kit

1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Human CXCL1 Detection Assay Kit

1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse CCL28 Detection Assay Kit

1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Disease Detection information

CF®488A TUNEL Assay Apoptosis Detection Kit

30063-1 KT
EUR 567

CF®640R TUNEL Assay Apoptosis Detection Kit

30074-1 KT
EUR 567

Human CD63 Expressed Exosome Detection Assay Kit

6037 1 kit
EUR 377
Description: Culture Media, Plasma, Serum, Purified Samples

Human Interleukin 6 (IL-6) Detection Assay Kit

6802 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Human Interleukin 4 (IL-4) Detection Assay Kit

6803 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Human Interleukin 1b (IL-1b) Detection Assay kit

6805 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Human Interleukin 17 (IL-17) Detection Assay Kit

6808 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Human Interleukin-5 (IL-5) Detection Assay Kit

6813 1 kit
EUR 357

Mouse Interleukin-6 (IL-6) Detection Assay Kit

6702 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse Interleukin-4 (IL-4) Detection Assay Kit

6703 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse Interleukin-2 (IL-2) Detection Assay Kit

6711 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse Interleukin-5 (IL-5) Detection Assay Kit

6713 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Human Interleukin-10 (IL-10) Detection Assay Kit

6806 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Human Interleukin-13 (IL-13) Detection Assay Kit

6812 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse Interleukin-17 (IL-17) Detection Assay Kit

6708 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse Interleukin-13 (IL-13) Detection Assay Kit

6712 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

Mouse Interleukin-23 (IL-23) Detection Assay Kit

6714 1 kit
EUR 357
Description: Culture Media, Serum, Plasma