An embedded gene choice methodology utilizing knockoffs optimizing

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An embedded gene choice methodology utilizing knockoffs optimizing neural community

 

Background: Gene alternative refers to find a small subset of discriminant genes from the gene expression profiles. The best way to decide on genes that affect specific phenotypic traits efficiently is an important evaluation work throughout the topic of biology. The neural neighborhood has increased turning into functionality when dealing with nonlinear data, and it’ll in all probability seize choices robotically and flexibly. On this work, we propose an embedded gene alternative methodology using neural neighborhood.

 

The important genes could also be obtained by calculating the burden coefficient after the teaching is achieved. In an effort to treatment the difficulty of black area of neural neighborhood and extra make the teaching outcomes interpretable in neural neighborhood, we use the idea of knockoffs to assemble the knockoff attribute genes of the distinctive attribute genes. This technique not solely make each attribute gene to compete with each other, however moreover make each attribute gene compete with its knockoff attribute gene. This methodology might assist to choose the essential factor genes that affect the decision-making of neural networks.

 

Outcomes: We use maize carotenoids, tocopherol methyltransferase, raffinose family oligosaccharides and human breast most cancers dataset to do verification and analysis.

 

Conclusions: The experiment outcomes show that the knockoffs optimizing neural neighborhood methodology has increased detection impression than the alternative current algorithms, and particularly for processing the nonlinear gene expression and phenotype data.

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Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus

 

 

Background: Crustaceans categorical numerous programs of receptor genes of their antennules, which house olfactory sensory neurons (OSNs) and non-olfactory chemosensory neurons. Transcriptomics analysis reveal that candidate chemoreceptor proteins embrace variant Ionotropic Receptors (IRs) along with every co-receptor IRs and tuning IRs, Transient Receptor Potential (TRP) channels, Gustatory Receptors, epithelial sodium channels, and class A G-protein coupled receptors (GPCRs). The Caribbean spiny lobster, Panulirus argus, expresses in its antennules virtually 600 IRs, 17 TRP channels, 1 Gustatory Receptor, 7 epithelial sodium channels, 81 GPCRs, 6 G proteins, and dozens of enzymes in signaling pathways.

 

However, the exact combinatorial expression patterns of these proteins in single sensory neurons normally usually are not acknowledged for any crustacean, limiting our understanding of how their chemosensory strategies encode chemical top quality.

 

Outcomes: The aim of this analysis was to utilize transcriptomics to clarify expression patterns of chemoreceptor genes in OSNs of P. argus. We generated and analyzed transcriptomes from 7 single OSNs, a couple of of which have been confirmed to reply a meals odor, along with an additional 7 multicell transcriptomes from preparations containing few (2-4), numerous (ca. 15), or many (ca. 400) OSNs. We found that each OSN expressed the similar 2 co-receptor IRs (IR25a, IR93a) nevertheless

 

not the alternative 2 antennular coIRs (IR8a, IR76b), 9-53 tuning IRs nevertheless only one to some in extreme abundance, the similar 5 TRP channels plus as a lot as 5 further TRPs, 12-17 GPCRs along with the similar 5 expressed in every single cell transcriptome, the similar Three G proteins plus others, many enzymes throughout the signaling pathways, nevertheless no Gustatory Receptors or epithelial sodium channels. The perfect distinction in receptor expression among the many many OSNs was the identification of the tuning IRs.

 

Conclusions: Our outcomes current an preliminary view of the combinatorial expression patterns of receptor molecules in single OSNs in a single species of decapod crustacean, along with receptors straight involved in olfactory transduction and others likely involved in modulation. Our outcomes moreover counsel variations in receptor expression in OSNs vs. completely different chemosensory neurons.

Camel Genetic Belongings Conservation by Tourism: A Key Sociocultural Methodology of Camelback Leisure Driving

 

  • Camels are distinctive components, which can be comprised inside journey journey companies promoting ecotourism actions. Such recreations contribute to sustainable livelihoods for native communities and educational empowerment within the route of nature and its conservation. At present, some native camel breeds’ survival reduces to this animal-based leisure enterprise and its reliability to hold out and promote custom-made corporations By conducting an on-site questionnaire to prospects collaborating in camelback driving excursions, we assessed the motivational parts affecting participation, satisfaction, and loyalty on this tourism section that can have made it socially differentiated.

 

  • The sixfold combination of employees effectivity, custom geography, quite a few and humane shut interaction, camel conduct and effectivity, sociotemporal context, and constructive earlier experience consists of the elemental dimensions that designate purchaser satisfaction and return intention probability inside this leisure enterprise.

 

  • Purchaser knowledge is essential for stakeholders to assemble personalised driving experiences and align earnings with environmental sustainability and biodiversity mainstream concerns into their frequently operations. In flip, house camel vacationer rides may be managed as a viable path to nature conservation by serving to endangered native breeds to stay away from their helpful devaluation and potential extinction.

 

Afatinib free base

MBS5756697-10mg 10mg
EUR 145

Afatinib free base

MBS5756697-200mg 200mg
EUR 250

Afatinib free base

MBS5756697-50mg 50mg
EUR 195

Afatinib free base

MBS5756697-5x200mg 5x200mg
EUR 965

Afatinib, Free Base [CAS# 850140-72-6]

A-8644 25 mg
EUR 46

Afatinib

27009 25 mg
EUR 115
Description: Afatinib, also known as BIW-2992, is an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinases. Afatinib suppresses EGF-induced EGFR phosphorylation and cellular proliferation in various cell lines, including EGFR-overexpressing and HER2-expressing cell lines A431, NIH-3T3-HER2, NCI-N87 and BT-474.

Afatinib

A355300 100mg
EUR 68
Description: 850140-72-6

Afatinib

A170-100MG 100mg
EUR 62.04
Description: C24H25ClFN5O3

Afatinib

GW6150 1mg
EUR 395.63

Afatinib

GW6150-1 1
EUR 171.5

Afatinib

GW6150-10 10
EUR 368.2

Afatinib

GW6150-5 5
EUR 237.4

Afatinib

HY-10261 200mg
EUR 374.4

Afatinib

T21312-10mg 10mg Ask for price
Description: Afatinib

Afatinib

T21312-1g 1g Ask for price
Description: Afatinib

Afatinib

T21312-1mg 1mg Ask for price
Description: Afatinib

Afatinib

T21312-50mg 50mg Ask for price
Description: Afatinib

Afatinib

T21312-5mg 5mg Ask for price
Description: Afatinib

Afatinib

MBS3842612-100mg 100mg
EUR 425

Afatinib

MBS3842612-10mg 10mg
EUR 140

Afatinib

MBS3842612-25mg 25mg
EUR 200

Afatinib

MBS3842612-50mg 50mg
EUR 275

Afatinib

MBS3842612-5x100mg 5x100mg
EUR 1910

Afatinib

MBS3604489-10mg 10mg
EUR 260

Afatinib

MBS3604489-25mg 25mg
EUR 325

Afatinib

MBS3604489-2mg 2mg
EUR 200

Afatinib

MBS3604489-50mg 50mg
EUR 435

Afatinib

MBS3604489-5mg 5mg
EUR 215

(R)-Afatinib

C597485 10mg
EUR 969
Description: 945553-91-3

(2Z)-Afatinib

A355305 0.5mg
EUR 2113
Description: 1680184-59-1

Afatinib D6

T10256-10mg 10mg Ask for price
Description: Afatinib D6

Afatinib D6

T10256-1g 1g Ask for price
Description: Afatinib D6

Afatinib D6

T10256-1mg 1mg Ask for price
Description: Afatinib D6

Afatinib D6

T10256-50mg 50mg Ask for price
Description: Afatinib D6

Afatinib D6

T10256-5mg 5mg Ask for price
Description: Afatinib D6

(R)-Afatinib

HY-10261E Get quote Ask for price
Description: (R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1].

Afatinib-d4

A355302 25mg
EUR 15000

Afatinib-d6

A355303 10mg
EUR 628
Description: 1313874-96-2

Afatinib-d6

HY-10261S 1 mg
EUR 616.89
Description: Afatinib-d6 is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor[1].

Afatinib-d4

HY-10261S1 1mg Ask for price
Description: Afatinib-d4 is the deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

Afatinib Dimer

A355310 25mg
EUR 12800

Afatinib oxalate

T64075-10mg 10mg Ask for price
Description: Afatinib oxalate

Afatinib oxalate

T64075-1g 1g Ask for price
Description: Afatinib oxalate

Afatinib oxalate

T64075-1mg 1mg Ask for price
Description: Afatinib oxalate

Afatinib oxalate

T64075-50mg 50mg Ask for price
Description: Afatinib oxalate

Afatinib oxalate

T64075-5mg 5mg Ask for price
Description: Afatinib oxalate

Afatinib (oxalate)

HY-10261D Get quote Ask for price
Description: Afatinib (BIBW 2992) oxalate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib oxalate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4].

Afatinib (BIBW2992)

A8247-10 10 mg
EUR 62
Description: Irreversible EGFR/HER2 inhibitor

Afatinib (BIBW2992)

A8247-5 5 mg
EUR 37
Description: Irreversible EGFR/HER2 inhibitor

Afatinib (BIBW2992)

A8247-5.1 10 mM (in 1mL DMSO)
EUR 55
Description: Irreversible EGFR/HER2 inhibitor

Afatinib (BIBW2992)

A8247-50 50 mg
EUR 86
Description: Irreversible EGFR/HER2 inhibitor

Afatinib (BIBW2992)

A8247-S Evaluation Sample
EUR 22
Description: Irreversible EGFR/HER2 inhibitor

Afatinib (BIBW2992)

MBS578066-10mg 10mg
EUR 195

Afatinib (BIBW2992)

MBS578066-25mg 25mg
EUR 260

Afatinib (BIBW2992)

MBS578066-2mg 2mg
EUR 145

Afatinib (BIBW2992)

MBS578066-50mg 50mg
EUR 370

Afatinib (BIBW2992)

MBS578066-5mg 5mg
EUR 155

BIBW2992 (Afatinib)

MBS386306-100mg 100mg
EUR 285

BIBW2992 (Afatinib)

MBS386306-10mg 10mg
EUR 140

BIBW2992 (Afatinib)

MBS386306-1mLinDMSO 1mL(inDMSO)
EUR 140

BIBW2992 (Afatinib)

MBS386306-25mg 25mg
EUR 160

BIBW2992 (Afatinib)

MBS386306-5mg 5mg
EUR 130

Afatinib dimaleate

120204 100.0mg
EUR 90

Afatinib Dimaleate

A355315 1g
EUR 126
Description: 850140-73-7

Afatinib dimaleate

A3145-10 10 mg
EUR 54
Description: EGFR inhibitor

Afatinib dimaleate

A3145-5 5 mg
EUR 33
Description: EGFR inhibitor

Afatinib dimaleate

A3145-5.1 10 mM (in 1mL DMSO)
EUR 48
Description: EGFR inhibitor

Afatinib dimaleate

A3145-50 50 mg
EUR 78
Description: EGFR inhibitor

Afatinib Dimaleate

T1773-10mg 10mg Ask for price
Description: Afatinib Dimaleate

Afatinib Dimaleate

T1773-1g 1g Ask for price
Description: Afatinib Dimaleate

Afatinib Dimaleate

T1773-1mg 1mg Ask for price
Description: Afatinib Dimaleate

Afatinib Dimaleate

T1773-50mg 50mg Ask for price
Description: Afatinib Dimaleate

Afatinib Dimaleate

T1773-5mg 5mg Ask for price
Description: Afatinib Dimaleate

Afatinib (dimaleate)

HY-10261A 200mg
EUR 374.4

Afatinib dimaleate

MBS3840747-100mg 100mg
EUR 240

Afatinib dimaleate

MBS3840747-25mg 25mg
EUR 165

Afatinib dimaleate

MBS3840747-50mg 50mg
EUR 200

Afatinib dimaleate

MBS3840747-5x100mg 5x100mg
EUR 1065

Afatinib dimaleate

MBS3606168-100mg 100mg
EUR 275

Afatinib dimaleate

MBS3606168-10mg 10mg
EUR 210

Afatinib dimaleate

MBS3606168-200mg 200mg
EUR 320

Afatinib dimaleate

MBS3606168-25mg 25mg
EUR 225

Afatinib dimaleate

MBS3606168-50mg 50mg
EUR 250

(E/Z)-Afatinib

HY-10261B 100 mg
EUR 54.11
Description: (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells[1].

BIBW 2992 (Afatinib)

abx283009-100g 100 µg Ask for price

BIBW 2992 (Afatinib)

abx283009-20g 20 µg
EUR 156.25

BIBW 2992 (Afatinib)

abx283009-50g 50 µg
EUR 387.5

(2Z)-Afatinib-d6

A355307 25mg
EUR 3000

Afatinib N-Oxide

A355330 25mg
EUR 1722

Afatinib N-Oxide

T10257-10mg 10mg Ask for price
Description: Afatinib N-Oxide

Afatinib N-Oxide

T10257-1g 1g Ask for price
Description: Afatinib N-Oxide

Afatinib N-Oxide

T10257-1mg 1mg Ask for price
Description: Afatinib N-Oxide

Afatinib N-Oxide

T10257-50mg 50mg Ask for price
Description: Afatinib N-Oxide

Afatinib N-Oxide

T10257-5mg 5mg Ask for price
Description: Afatinib N-Oxide

Afatinib N-Oxide

HY-133110 Get quote Ask for price
Description: Afatinib N-Oxide is an impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor[1].

Afatinib impurity 11

T35430-10mg 10mg Ask for price
Description: Afatinib impurity 11

Afatinib impurity 11

T35430-1g 1g Ask for price
Description: Afatinib impurity 11

Afatinib impurity 11

T35430-1mg 1mg Ask for price
Description: Afatinib impurity 11

Afatinib impurity 11

T35430-50mg 50mg Ask for price
Description: Afatinib impurity 11

Afatinib impurity 11

T35430-5mg 5mg Ask for price
Description: Afatinib impurity 11

Afatinib impurity 11

MBS5796779-1mg 1(mg
EUR 185

Afatinib impurity 11

MBS5796779-5mg 5(mg
EUR 345

Afatinib impurity 11

MBS5796779-5x5mg 5x5(mg
EUR 1410

Afatinib impurity 11

HY-133780 1 mg
EUR 1439.42
Description: Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].

3-Dechloro Afatinib

D226460 250mg
EUR 3000

Afatinib-d6 Dimaleate

A355317 10mg
EUR 437

Afatinib-d6 (dimaleate)

HY-10261AS 1mg Ask for price
Description: Afatinib-d6 (dimaleate) is the deuterium labeled Afatinib dimaleate. Afatinib dimaleate is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1][2].

Afatinib (BIBW2992) Dimaleate

MBS577991-100mg 100mg
EUR 215

Afatinib (BIBW2992) Dimaleate

MBS577991-10mg 10mg
EUR 145

Afatinib (BIBW2992) Dimaleate

MBS577991-200mg 200mg
EUR 255

Afatinib (BIBW2992) Dimaleate

MBS577991-25mg 25mg
EUR 165

Afatinib (BIBW2992) Dimaleate

MBS577991-5mg 5mg
EUR 145

Afatinib Impurity AFT-8

A355335 100mg
EUR 1028
Description: 2323570-72-3

N3-(3-Dimethylamino,1-carboxyprop-2-yl) Afatinib

D471315 25mg
EUR 11200

EGFR/HER2 kinase inhibitor (>99%, M.wt 485.94) (Afatinib/BIBW-2992

SM-101000-5 5 mg
EUR 196.8

EGFR/HER2 kinase inhibitor (>99%, M.wt 485.94) (Afatinib/BIBW-2992

SM-101000-50 50 mg
EUR 781.2

Diethyl (S)-2-Amino-2-oxoethyl Phosphonate Afatinib

D355300 250mg
EUR 800
Description: 618061-76-0

Des(N,N-Dimethylprop-2-enyl-1-Amine) Afatinib

D291240 10mg
EUR 1631

3-Dechloro-4-defluoro 4-Chloro-3-fluoro Afatinib

D226455 100mg
EUR 3000

Deschloro-N-des(4-dimethylamino-2-en-1-oxo)butyl Afatinib

D289625 1g
EUR 1800

Desfluoro-N-des(4-dimethylamino-2-en-1-oxo)butyl Afatinib

D289815 2.5g
EUR 1800
Description: 2413212-09-4

Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)

A355320 100mg
EUR 276
Description: 314771-76-1

Deschloro,desfluoro-N-des(4-dimethylamino-2-en-1-oxo)butyl Afatinib

D289635 2.5g
EUR 1800

Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(pyrrolidin-2,5-dion-1-yl) Afatinib

D291238 100mg
EUR 316

Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Amino-pyrrolidin-2-on-1-yl) Afatinib

D291248 10mg
EUR 759

Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib

D291245 10mg
EUR 874

Afamelanotide free base

330224 1.0mg
EUR 265

I-37 free base( 2359690-13-2(free base))

T8721L-10mg 10mg Ask for price
Description: I-37 free base( 2359690-13-2(free base))

I-37 free base( 2359690-13-2(free base))

T8721L-1g 1g Ask for price
Description: I-37 free base( 2359690-13-2(free base))

I-37 free base( 2359690-13-2(free base))

T8721L-1mg 1mg Ask for price
Description: I-37 free base( 2359690-13-2(free base))

I-37 free base( 2359690-13-2(free base))

T8721L-50mg 50mg Ask for price
Description: I-37 free base( 2359690-13-2(free base))

I-37 free base( 2359690-13-2(free base))

T8721L-5mg 5mg Ask for price
Description: I-37 free base( 2359690-13-2(free base))

I-37 free base (2359690-13-2(free base))

MBS5759495-10mg 10mg
EUR 470

I-37 free base (2359690-13-2(free base))

MBS5759495-1mg 1mg
EUR 210

I-37 free base (2359690-13-2(free base))

MBS5759495-25mg 25mg
EUR 780

I-37 free base (2359690-13-2(free base))

MBS5759495-50mg 50mg
EUR 1130

I-37 free base (2359690-13-2(free base))

MBS5759495-5mg 5mg
EUR 335

EDC free base

GM6988 5g
EUR 116.06

TMB free base

TB0954 1g
EUR 85.06

S107 free base

530577 100.0mg
EUR 750

THZ1 (Free base)

9664-25 each
EUR 1227.6

THZ1 (Free base)

9664-5 each
EUR 352.8

K201 free base

414202 5.0mg
EUR 288

FIPI free base

407955 200.0mg
EUR 1050

R406(free base)

E1KS1533 2mg
EUR 362.4

FIPI (free base)

B2372-25 each
EUR 757.2

FIPI (free base)

B2372-5 each
EUR 235.2

NG25 free base

562503 5.0mg
EUR 485

R406 (free base)

A5880-100 100 mg
EUR 800
Description: Syk inhibitor

R406 (free base)

A5880-25 25 mg
EUR 320
Description: Syk inhibitor

R406 (free base)

A5880-5 5 mg
EUR 80
Description: Syk inhibitor

R406 (free base)

A5880-5.1 10 mM (in 1mL DMSO)
EUR 148
Description: Syk inhibitor

R406 (free base)

A5880-S Evaluation Sample
EUR 22
Description: Syk inhibitor

R406(free base)

MBS131267-100mg 100mg
EUR 1065

R406(free base)

MBS131267-500mg 500mg
EUR 2775

R406 (free base)

HY-11108 10mM/1mL
EUR 277.2

R406 free base

T2467-10mg 10mg Ask for price
Description: R406 free base

R406 free base

T2467-1g 1g Ask for price
Description: R406 free base

R406 free base

T2467-1mg 1mg Ask for price
Description: R406 free base

R406 free base

T2467-50mg 50mg Ask for price
Description: R406 free base

R406 free base

T2467-5mg 5mg Ask for price
Description: R406 free base

SIS3 free base

T12923-10mg 10mg Ask for price
Description: SIS3 free base

SIS3 free base

T12923-1g 1g Ask for price
Description: SIS3 free base

SIS3 free base

T12923-1mg 1mg Ask for price
Description: SIS3 free base

SIS3 free base

T12923-50mg 50mg Ask for price
Description: SIS3 free base

SIS3 free base

T12923-5mg 5mg Ask for price
Description: SIS3 free base

R406 (free base)

MBS8506526-2mg 2mg
EUR 440

R406 (free base)

MBS8506526-5x2mg 5x2mg
EUR 1835

R406 free base

MBS3606124-10mg 10mg
EUR 305

R406 free base

MBS3606124-25mg 25mg
EUR 405

R406 free base

MBS3606124-2mg 2mg
EUR 235

R406 free base

MBS3606124-50mg 50mg
EUR 620

R406 free base

MBS3606124-5mg 5mg
EUR 260

R788 free base

MBS3606474-10mg 10mg
EUR 315

R788 free base

MBS3606474-25mg 25mg
EUR 430

R788 free base

MBS3606474-2mg 2mg
EUR 225

R788 free base

MBS3606474-5mg 5mg
EUR 260

R788 free base

MBS3606474-5x25mg 5x25mg
EUR 1620

SIS3 free base

MBS5767611-5mg 5mg
EUR 915

SIS3 free base

MBS5767611-5x5mg 5x5mg
EUR 3970

SIS3 (free base)

HY-100444 10 mg
EUR 1244.61
Description: SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2[1].

ML355 free base

533249 50.0mg
EUR 350

ML241 free base

406621 10.0mg
EUR 90

MS023 free base

407274 10.0mg
EUR 150

LYS01 free base

407398 10.0mg
EUR 150

ML298 free base

407464 5.0mg
EUR 240

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